{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:49:40Z","timestamp":1790261380967,"version":"4.1.0"},"reference-count":33,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Patients with spondyloarthritis (SpA) receiving anti-TNF-\u03b1 treatment have an increase in fat mass. This may be relevant to cardiovascular risk. The aim of this study was to estimate visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) changes by dual-energy x-ray absorptiometry (DEXA) in patients with SpA under anti-TNF-\u03b1 therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We used an ancillary protocol to an open, prospective 2-year followup study of patients with SpA. Waist circumference (WC), body weight, body mass index, VAT, and SAT were measured at baseline, 6 months, and 1 and 2 years. Univariate and multivariate analyses were performed to assess variables associated with VAT and SAT changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>A total of 85 patients were analyzed. Patients were 39.3 \u00b1 11.4 years old and mean baseline Bath Ankylosing Spondylitis Disease Activity Index was 55.0 \u00b1 20.2. Treatment was effective according to clinical and biological variables, and body weight increased by 0.9 \u00b1 1.7 kg over 2 years. There was a significant gain in VAT after 6 months (13.7 \u00b1 20.6 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001), 1 year (21.0 \u00b1 26.6 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001), and after 2 years (29.1 \u00b1 33.4 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001); and in SAT after 6 months (12.5 \u00b1 27.4 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001), 1 year (27.1 \u00b1 38.2 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001), and after 2 years (31.9 \u00b1 53.2 cm<jats:sup>2<\/jats:sup>, p &lt; 0.0001). We could not find any determinant of these changes by multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In patients with SpA receiving anti-TNF-\u03b1 therapy, there is an early significant increase in abdominal obesity with significant increase in both VAT and SAT after 1 and 2 years of treatment. Prospective studies are required to investigate the relationship between these changes and cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131150","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T22:05:37Z","timestamp":1397599537000},"page":"1112-1117","source":"Crossref","is-referenced-by-count":34,"title":["Early Increase of Abdominal Adiposity in Patients with Spondyloarthritis Receiving Anti-tumor Necrosis Factor-\u03b1 Treatment"],"prefix":"10.3899","volume":"41","author":[{"given":"Ihsane","family":"Hmamouchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Paternotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Kolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Briot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"2018112909325347000_41.6.1112.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"2018112909325347000_41.6.1112.2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1346::AID-ANR18>3.0.CO;2-E"},{"key":"2018112909325347000_41.6.1112.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.028670"},{"key":"2018112909325347000_41.6.1112.4","first-page":"855","article-title":"Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumor necrosis factor-alpha treatment","volume":"35","author":"Briot","year":"2008","journal-title":"J Rheumatol"},{"key":"2018112909325347000_41.6.1112.5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0026-0495(03)00072-6","article-title":"Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction","volume":"2","author":"Phillips","year":"2003","journal-title":"Metabolism"},{"key":"2018112909325347000_41.6.1112.6","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198606000-00007"},{"key":"2018112909325347000_41.6.1112.7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/ajcn\/48.6.1351","article-title":"Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: predictive equations","volume":"48","author":"Kvist","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"2018112909325347000_41.6.1112.8","first-page":"1","article-title":"Accuracy of estimating intraabdominal fat in obese women","volume":"6","author":"Ball","year":"2003","journal-title":"J Exerc Physiol Online"},{"key":"2018112909325347000_41.6.1112.9","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/38447238"},{"key":"2018112909325347000_41.6.1112.10","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.367"},{"key":"2018112909325347000_41.6.1112.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051042"},{"key":"2018112909325347000_41.6.1112.12","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.393"},{"key":"2018112909325347000_41.6.1112.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"2018112909325347000_41.6.1112.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2018112909325347000_41.6.1112.15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"2018112909325347000_41.6.1112.16","first-page":"i","volume-title":"Obesity: preventing and managing the global epidemic","volume":"894","year":"2000"},{"key":"2018112909325347000_41.6.1112.17","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.2.203"},{"key":"2018112909325347000_41.6.1112.18","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.43"},{"key":"2018112909325347000_41.6.1112.19","unstructured":"Bray G Bouchard C James W . 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