{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:58:44Z","timestamp":1788472724978,"version":"build-2803163510"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate the association between hyperuricemia and renal disease progression in a real-world, large observational database study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We conducted a population-based retrospective cohort study identifying 111,992 patients with hyperuricemia (&gt; 7 mg\/dl) from a large medical group. The final cohort were \u2265 18 years old, urate-lowering therapy (ULT)-na\u00efve, and had the following laboratory results available: at least 1 glomerular filtration rate (GFR) level before the index date and at least 1 serum uric acid (sUA) level and GFR in the followup 36-month period. The cohort was categorized into 3 groups: never treated (NoTx), ULT time receiving therapy of &lt; 80% (&lt; 80%), and ULT time receiving therapy of \u2265 80% (\u2265 80%). Outcomes were defined as a \u2265 30% reduction in GFR from baseline, dialysis, or GFR of \u2264 15 ml\/min. A subanalysis of patients with sUA &lt; 6 mg\/dl at study conclusion was performed. Cox proportional hazards regression model determined factors associated with renal function decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>A total of 16,186 patients met inclusion criteria. There were 11,192 NoTx patients, 3902 with &lt; 80% time receiving ULT, and 1092 with \u2265 80% time receiving ULT. Factors associated with renal disease progression were age, sex, hypertension, diabetes, congestive heart failure, hospitalizations, rheumatoid arthritis, and higher sUA at baseline. Time receiving therapy was not associated with renal outcomes. Patients who achieved sUA &lt; 6 mg\/dl had a 37% reduction in outcome events (p &lt; 0.0001; HR 0.63, 95% CI: 0.5\u20130.78).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Hyperuricemia is an independent risk factor for renal function decline. Patients treated with ULT who achieved sUA &lt; 6 mg\/dl on ULT showed a 37% reduction in outcome events.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131159","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T23:19:19Z","timestamp":1396394359000},"page":"955-962","source":"Crossref","is-referenced-by-count":62,"title":["Effect of Urate-lowering Therapies on Renal Disease Progression in Patients with Hyperuricemia"],"prefix":"10.3899","volume":"41","author":[{"given":"Gerald D.","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Craig","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"2018112909324638000_41.5.955.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"2018112909324638000_41.5.955.2","first-page":"e46","article-title":"Ambulatory resource utilization and cost for gout in the United States","volume":"5","author":"Li","year":"2013","journal-title":"Am J Pharm Benefits"},{"key":"2018112909324638000_41.5.955.3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7812\/TPP\/12-031","article-title":"Sociodemographic characteristics of members of a large, integrated health care system comparison with US Census Bureau data","volume":"16","author":"Koebnick","year":"2012","journal-title":"Perm J"},{"key":"2018112909324638000_41.5.955.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"2018112909324638000_41.5.955.5","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.691"},{"key":"2018112909324638000_41.5.955.6","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008010080"},{"key":"2018112909324638000_41.5.955.7","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007101075"},{"key":"2018112909324638000_41.5.955.8","doi-asserted-by":"publisher","DOI":"10.1159\/000105142"},{"key":"2018112909324638000_41.5.955.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.1.59"},{"key":"2018112909324638000_41.5.955.10","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.10.006"},{"key":"2018112909324638000_41.5.955.11","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01580210"},{"issue":"Suppl 10","key":"2018112909324638000_41.5.955.12","first-page":"S68","article-title":"The effect of allopurinol on renal function in patients with hyperuricemia: a case-control study","volume":"62","author":"Krishnamurthy","year":"2010","journal-title":"Arthritis Rheum"},{"key":"2018112909324638000_41.5.955.13","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9253-3"},{"key":"2018112909324638000_41.5.955.14","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.092839"},{"key":"2018112909324638000_41.5.955.15","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000034910.58454.FD"},{"key":"2018112909324638000_41.5.955.16","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes211"},{"key":"2018112909324638000_41.5.955.17","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21791"},{"key":"2018112909324638000_41.5.955.18","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21824"},{"key":"2018112909324638000_41.5.955.19","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"2018112909324638000_41.5.955.20","doi-asserted-by":"publisher","DOI":"10.1002\/art.33369"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.131159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T13:43:12Z","timestamp":1543498992000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.131159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,1]]},"published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.3899\/jrheum.131159"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.131159","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}