{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:58:23Z","timestamp":1793069903067,"version":"4.5.0"},"reference-count":25,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess ovarian reserve markers in patients with Takayasu arteritis (TA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Twenty patients with TA and 24 healthy controls were evaluated for ovarian reserve by follicle-stimulating hormone, luteinizing hormone, and estradiol, and antral follicle count (AFC). Anti-M\u00fcllerian hormone (AMH) was measured by ELISA using 2 different kits. Demographical data, menstrual abnormalities, disease variables, and treatment were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The median current age was similar in patients with TA and controls (31.2 \u00b1 6.1 vs 30.4 \u00b1 6.9 yrs, p = 0.69). The frequencies of decreased levels of AMH in patients with TA were identical using both kits and higher when compared to controls (50% vs 17%, p = 0.02; 50% vs 19%, p = 0.048). A positive correlation was observed between the 2 kits in patients with TA (r = +0.93, p &lt; 0.0001) and in healthy controls (r = +0.93, p &lt; 0.0001). The apparent lower AFC (11 vs 16, p = 0.13) and the higher frequency of low AFC (41% vs 22%, p = 0.29) in TA compared to controls did not reach statistical significance. Other hormones were similar in both groups (p &gt; 0.05). Further evaluation of patients with TA with low AMH levels (&lt; 1.0 ng\/ml) versus normal AMH levels (&gt; 1.0 ng\/ml) revealed that the frequency of current disease activity (p = 1.0) and the median of erythrocyte sedimentation rate (p = 0.6), C-reactive protein (p = 0.4), prednisone cumulative dose (p = 0.8), and methotrexate cumulative dose (p = 0.8) were comparable in both groups. Cyclophosphamide use was reported in only 1 patient with reduced ovarian reserve, whereas none of the remaining patients received gonadotoxic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>To the best of our knowledge, our present study was the first to suggest that patients with TA may have diminished ovarian reserve.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131360","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T00:29:20Z","timestamp":1408148960000},"page":"2055-2059","source":"Crossref","is-referenced-by-count":32,"title":["Reduced Ovarian Reserve in Patients with Takayasu Arteritis"],"prefix":"10.3899","volume":"41","author":[{"given":"Andrea Rocha S.","family":"Mont\u2019Alverne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria R.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Yugo S.","family":"Yamakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma Santos T.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund Chada","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Bonf\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis Artur","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"2018112909333025000_41.10.2055.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1695-4033(03)78039-4"},{"key":"2018112909333025000_41.10.2055.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.006353"},{"key":"2018112909333025000_41.10.2055.3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307077538"},{"key":"2018112909333025000_41.10.2055.4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20323"},{"key":"2018112909333025000_41.10.2055.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.003"},{"key":"2018112909333025000_41.10.2055.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq350"},{"key":"2018112909333025000_41.10.2055.7","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu219oa"},{"key":"2018112909333025000_41.10.2055.8","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307079300"},{"key":"2018112909333025000_41.10.2055.9","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308094652"},{"key":"2018112909333025000_41.10.2055.10","first-page":"571","article-title":"Menstrual and hormonal alterations in juvenile dermatomyositis","volume":"28","author":"Aikawa","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909333025000_41.10.2055.11","first-page":"445","article-title":"Subclinical impairment of ovarian reserve in juvenile systemic lupus erythematosus after cyclophosphamide therapy","volume":"30","author":"Aikawa","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909333025000_41.10.2055.12","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/art.1780330811","article-title":"The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis","volume":"33","author":"Arend","year":"1990","journal-title":"Arthritis Rheum"},{"key":"2018112909333025000_41.10.2055.13","unstructured":"Almeida PM Wickerhauser W . 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