{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T10:21:04Z","timestamp":1695896464926},"reference-count":17,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and hyperplasia. Tumor necrosis factor-\u03b1 (TNF-\u03b1) plays a pivotal role in RA by interfering with the Fas\u2013Fas ligand (FasL) proapoptotic pathway. We investigated the circulating levels of soluble Fas (sFas) and soluble FasL (sFasL), and their possible correlation with disease activity and improvement after anti-TNF-\u03b1 treatment in RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Serum levels of sFas and sFasL were measured by quantitative ELISA in 52 patients with RA before and after 3 months of anti-TNF-\u03b1 treatment (adalimumab, n = 32; infliximab, n = 20). Disease activity measures [Disease Activity Score at 28 joints-erythrocyte sedimentation rate (DAS28-ESR), C-reactive protein (CRP)] were recorded before and after treatment. Forty age-matched and sex-matched healthy subjects served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>No significant differences in serum sFas levels were detected between anti-TNF-\u03b1-naive patients with RA and controls. After anti-TNF-\u03b1 treatment, serum sFas levels significantly increased in patients with RA compared to both anti-TNF-\u03b1-naive patients and controls. Increased sFas levels inversely correlated with disease activity variables (DAS28-ESR: r = \u22120.739, CRP: r = \u22120.636, both p &lt; 0.001). No significant differences in sFasL levels were detected in patients with RA before and after anti-TNF-\u03b1 treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In RA, an increase in sFas levels closely correlates with improvement in disease activity induced by TNF-\u03b1 inhibitors, suggesting their ability to modulate Fas-mediated synoviocyte apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131544","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T03:46:07Z","timestamp":1409629567000},"page":"1961-1965","source":"Crossref","is-referenced-by-count":4,"title":["Disease Activity Improvement in Rheumatoid Arthritis Treated with Tumor Necrosis Factor-\u03b1 Inhibitors Correlates with Increased Soluble Fas Levels"],"prefix":"10.3899","volume":"41","author":[{"given":"Eloisa","family":"Romano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Terenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Manetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Peruzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginevra","family":"Fiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Nacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Bellando-Randone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Matucci-Cerinic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Guiducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"2018112909333025000_41.10.1961.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"2018112909333025000_41.10.1961.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0317-y"},{"key":"2018112909333025000_41.10.1961.3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/1529-0131(200101)44:1<21::AID-ANR4>3.0.CO;2-8","article-title":"Rheumatoid 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