{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:11:56Z","timestamp":1761718316126},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (<jats:italic>cGKII\/PRKG2<\/jats:italic>) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of <jats:italic>cGKII<\/jats:italic> was performed in 741 male gout patients and 1302 male controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p><jats:italic>cGKII<\/jats:italic> variants have no association with gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our replication study suggests that <jats:italic>cGKII<\/jats:italic> is not involved in gout susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.131548","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:12:33Z","timestamp":1401667953000},"page":"1395-1397","source":"Crossref","is-referenced-by-count":4,"title":["Common Variants of <i>cGKII\/PRKG2<\/i> Are Not Associated with Gout 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