{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:22:09Z","timestamp":1784197329399,"version":"3.55.0"},"reference-count":29,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Increased levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cardiovascular morbidity and mortality. Inflammation may also affect levels of NT-proBNP. We investigated the relationship of NT-proBNP with inflammation, disease activity, disease severity, and progression of Takayasu arteritis (TA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Plasma levels of NT-proBNP were determined in 68 patients with TA and in 90 control subjects. Disease activity and disease severity in patients with TA were defined according to the National Institutes of Health and Ishikawa\u2019s criteria, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>NT-proBNP levels were higher in patients with active disease (915.0 \u00b1 328.0 pmol\/l) and patients in remission (618.2 \u00b1 243.4 pmol\/l) than in controls (427.2 \u00b1 81.4 pmol\/l) (p &lt; 0.001). Patients with severe TA showed significantly higher NT-proBNP levels than those with mild-moderate TA (924.0 \u00b1 332.4 pmol\/l vs 653.8 \u00b1 269.1 pmol\/l; p = 0.001). In patients with longitudinal data, NT-proBNP levels at the active phase were significantly higher than those at the stable phase (944.1 \u00b1 216.7 pmol\/l vs 552.1 \u00b1 178.2 pmol\/l; p = 0.001). Inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate, and white blood cell count, were independently associated with NT-proBNP levels after adjustment for other confounding factors (R<jats:sup>2<\/jats:sup>adjusted = 0.307, p = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>NT-proBNP levels were significantly increased in patients with active TA exhibiting complications. NT-proBNP levels were independently associated with inflammation. These results indicate that NT-proBNP may be a useful marker to assess the status, severity, and progression of TA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.140113","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T04:56:46Z","timestamp":1405486606000},"page":"1683-1688","source":"Crossref","is-referenced-by-count":10,"title":["Function of N-Terminal Pro-Brain Natriuretic Peptide in Takayasu Arteritis Disease Monitoring"],"prefix":"10.3899","volume":"41","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naqiang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"2018112909333262000_41.8.1683.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.3.429"},{"key":"2018112909333262000_41.8.1683.2","first-page":"S9","article-title":"Takayasu arteritis: Clinical features in 110 Mexican Mestizo patients and cardiovascular impact on survival and prognosis","volume":"26","author":"Soto","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909333262000_41.8.1683.3","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510026526"},{"key":"2018112909333262000_41.8.1683.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.094"},{"key":"2018112909333262000_41.8.1683.5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-11-199406010-00004"},{"key":"2018112909333262000_41.8.1683.6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0889-857X(21)00484-1","article-title":"Takayasu\u2019s arteritis","volume":"21","author":"Kerr","year":"1995","journal-title":"Rheum Dis Clin North Am"},{"key":"2018112909333262000_41.8.1683.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390507"},{"key":"2018112909333262000_41.8.1683.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"2018112909333262000_41.8.1683.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041661.63285.AE"},{"key":"2018112909333262000_41.8.1683.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042330"},{"key":"2018112909333262000_41.8.1683.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.01.001"},{"key":"2018112909333262000_41.8.1683.12","doi-asserted-by":"publisher","DOI":"10.1177\/147323000403200109"},{"key":"2018112909333262000_41.8.1683.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.09.025"},{"key":"2018112909333262000_41.8.1683.14","doi-asserted-by":"crossref","first-page":"I21","DOI":"10.1161\/CIRCULATIONAHA.105.000513","article-title":"Gene expression profiles and B-type natriuretic peptide elevation in heart transplantation: More than a hemodynamic marker","volume":"114","author":"Mehra","year":"2006","journal-title":"Circulation"},{"key":"2018112909333262000_41.8.1683.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.23796"},{"key":"2018112909333262000_41.8.1683.16","first-page":"1314","article-title":"N-terminal pro-brain natriuretic peptide in systemic lupus erythematosus: Relationship with inflammation, augmentation index, and coronary calcification","volume":"35","author":"Chung","year":"2008","journal-title":"J Rheumatol"},{"key":"2018112909333262000_41.8.1683.17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei274"},{"key":"2018112909333262000_41.8.1683.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.12.018"},{"key":"2018112909333262000_41.8.1683.19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/art.1780330811","article-title":"The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis","volume":"33","author":"Arend","year":"1990","journal-title":"Arthritis Rheum"},{"key":"2018112909333262000_41.8.1683.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80178-6"},{"key":"2018112909333262000_41.8.1683.21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1855"},{"key":"2018112909333262000_41.8.1683.22","first-page":"347","article-title":"The 2002\/3 Canadian Cardiovascular Society consensus guideline update for the diagnosis and management of heart failure","volume":"19","author":"Liu","year":"2003","journal-title":"Can J Cardiol"},{"key":"2018112909333262000_41.8.1683.23","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2783"},{"key":"2018112909333262000_41.8.1683.24","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2182-x"},{"key":"2018112909333262000_41.8.1683.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.55"},{"key":"2018112909333262000_41.8.1683.26","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110231"},{"key":"2018112909333262000_41.8.1683.27","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0140-z"},{"key":"2018112909333262000_41.8.1683.28","doi-asserted-by":"publisher","DOI":"10.1159\/000094720"},{"key":"2018112909333262000_41.8.1683.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.08.004"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.140113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T04:55:28Z","timestamp":1649652928000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.140113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,15]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,1]]},"published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.3899\/jrheum.140113"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.140113","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,15]]}}}