{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:03:46Z","timestamp":1793930626441,"version":"4.8.0"},"reference-count":58,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To investigate the association between polymyositis (PM)\/dermatomyositis (DM) and risks of malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We searched Pubmed for articles dated before August 16, 2013. Studies were included if they met the following criteria: (1) a cohort or observational study; (2) PM or DM as one of the exposures of interest; (3) cancer as an outcome of interest; and (4) the rate ratio (RR) or standardized incidence ratio (SIR) were available with their 95% CI. We used random-effects or fixed-effects models to calculate the pooled RR according to the heterogeneity test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Twenty publications were included. Compared with the general population, the pooled RR for patients with PM, DM, and PM\/DM were 1.62 (95% CI 1.19\u20132.04), 5.50 (4.31\u20136.70), and 4.07 (3.02\u20135.12), respectively. The increased risks were more significant in patients within the first year of myositis diagnosis, male patients, and population-based studies (for DM). A significant association was also found between PM or DM and most site-specific malignancies. However, both PM and DM were not associated with stomach and prostate cancers. Significant heterogeneity was found between studies on association between PM\/DM and overall malignancy, but not between PM\/DM and the majority of site-specific malignancies, suggesting that that inherent malignancy difference may be a major source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>The present metaanalysis indicates that PM and DM are significantly associated with increased risks of overall malignancy and most site-specific malignancies. The number of studies on association between PM or DM and some malignancies is too small to draw a firm conclusion. Accordingly, more research is needed for these malignancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.140566","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T23:37:27Z","timestamp":1417477047000},"page":"282-291","source":"Crossref","is-referenced-by-count":161,"title":["Polymyositis\/dermatomyositis and Malignancy Risk: A Metaanalysis Study"],"prefix":"10.3899","volume":"42","author":[{"given":"Zaixing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baodong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,12,1]]},"reference":[{"key":"2018112909335593000_42.2.282.1","first-page":"197","article-title":"Epidemiology of polymyositis-dermatomyositis in Israel, 1960\u201376","volume":"16","author":"Benbassat","year":"1980","journal-title":"Isr J Med Sci"},{"key":"2018112909335593000_42.2.282.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80006-7"},{"key":"2018112909335593000_42.2.282.3","first-page":"1329","article-title":"Incidence of polymyositis-dermatomyositis: a 20-year study of hospital diagnosed cases in Allegheny County, PA 1963\u20131982","volume":"17","author":"Oddis","year":"1990","journal-title":"J Rheumatol"},{"key":"2018112909335593000_42.2.282.4","first-page":"445","article-title":"Epidemiology of sporadic inclusion body myositis and polymyositis in Olmsted County, Minnesota","volume":"35","author":"Wilson","year":"2008","journal-title":"J Rheumatol"},{"key":"2018112909335593000_42.2.282.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.1995.tb02223.x"},{"key":"2018112909335593000_42.2.282.6","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600622132"},{"key":"2018112909335593000_42.2.282.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"2018112909335593000_42.2.282.8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-103"},{"key":"2018112909335593000_42.2.282.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00021-2"},{"key":"2018112909335593000_42.2.282.10","first-page":"1855","article-title":"The overall and temporal association of cancer with polymyositis and dermatomyositis","volume":"21","author":"Zantos","year":"1994","journal-title":"J Rheumatol"},{"key":"2018112909335593000_42.2.282.11","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/bjd.12564","article-title":"Meta-analysis of the association of dermatomyositis and polymyositis with cancer","volume":"169","author":"Wang","year":"2013","journal-title":"Br J Dermatol"},{"key":"2018112909335593000_42.2.282.12","unstructured":"Wells GA Shea B O\u2019Connell D Peterson J Welch V Losos M The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 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