{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:21Z","timestamp":1791300501551,"version":"4.1.0"},"reference-count":52,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Syndecan-1 (SDC-1) is a major constituent of the endothelial glycocalyx, which plays a role in maintaining vascular homeostasis and functions as a glomerular filtration barrier. SDC-1 is readily shed into the blood under various conditions, but the clinical implication of circulating SDC-1 in patients with systemic lupus erythematosus (SLE) remains unclear. We aimed to investigate the association of serum SDC-1 level with certain clinical manifestations of SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We measured serum SDC-1 levels by ELISA in 111 patients with SLE, 18 with rheumatoid arthritis (RA), and 20 healthy subjects, and investigated its association with clinical manifestations and laboratory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Serum SDC-1 levels were higher in patients with SLE than in those with RA and healthy controls (both p &lt; 0.001) and were positively correlated with SLE Disease Activity Index (SLEDAI; r = 0.367, p &lt; 0.001) and anti-dsDNA antibody level (r = 0.259, p = 0.007), but inversely correlated with serum C3 and CH50 levels (r = \u22120.305, p = 0.001 and r = \u22120.244, p = 0.012). Patients with active nephritis had higher serum SDC-1 levels than patients with inactive nephritis and those without nephritis (both p &lt; 0.001). In addition, serum SDC-1 levels were correlated with renal SLEDAI score (r = 0.540, p &lt; 0.001) and excretion of proteinuria as measured by spot urine protein\/creatinine ratio (r = 0.538, p &lt; 0.001). In 14 patients with lupus nephritis (LN) whose serum samples were obtained at the time of renal biopsy, there was a positive correlation between serum SDC-1 levels and activity index (r = 0.632, p = 0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Serum SDC-1 levels are increased in SLE patients with nephritis, indicating that SDC-1 might be a useful serum biomarker for active LN.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.140568","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T04:59:02Z","timestamp":1418705942000},"page":"202-209","source":"Crossref","is-referenced-by-count":46,"title":["Elevated Serum Levels of Syndecan-1 Are Associated with Renal Involvement in Patients with Systemic Lupus Erythematosus"],"prefix":"10.3899","volume":"42","author":[{"given":"Ki-Jo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Woon","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Soo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"2018112909335588000_42.2.202.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.08.018"},{"key":"2018112909335588000_42.2.202.2","first-page":"1464","article-title":"Early diagnosis and treatment in lupus nephritis: how we can influence the risk for terminal renal failure","volume":"33","author":"Fiehn","year":"2006","journal-title":"J Rheumatol"},{"key":"2018112909335588000_42.2.202.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.435"},{"key":"2018112909335588000_42.2.202.4","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03530509"},{"key":"2018112909335588000_42.2.202.5","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920730"},{"key":"2018112909335588000_42.2.202.6","doi-asserted-by":"publisher","DOI":"10.1186\/ar3528"},{"key":"2018112909335588000_42.2.202.7","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1681\/ASN.V1271369","article-title":"Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis","volume":"12","author":"Perez de Lema","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2018112909335588000_42.2.202.8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq860"},{"key":"2018112909335588000_42.2.202.9","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.032"},{"key":"2018112909335588000_42.2.202.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.10.014"},{"key":"2018112909335588000_42.2.202.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0330-4"},{"key":"2018112909335588000_42.2.202.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000074316.76104.A5"},{"key":"2018112909335588000_42.2.202.13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1182\/blood.V95.2.388","article-title":"Serum syndecan-1: a new independent prognostic marker in multiple myeloma","volume":"95","author":"Seidel","year":"2000","journal-title":"Blood"},{"key":"2018112909335588000_42.2.202.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.02.015"},{"key":"2018112909335588000_42.2.202.15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121181"},{"key":"2018112909335588000_42.2.202.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.684852"},{"key":"2018112909335588000_42.2.202.17","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.545846"},{"key":"2018112909335588000_42.2.202.18","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2018112909335588000_42.2.202.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2018112909335588000_42.2.202.20","doi-asserted-by":"publisher","DOI":"10.1002\/art.21625"},{"key":"2018112909335588000_42.2.202.21","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"2018112909335588000_42.2.202.22","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90338-8"},{"key":"2018112909335588000_42.2.202.23","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"2018112909335588000_42.2.202.24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.7166"},{"key":"2018112909335588000_42.2.202.25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.9.060906.151959"},{"key":"2018112909335588000_42.2.202.26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.187831"},{"key":"2018112909335588000_42.2.202.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.01.013"},{"key":"2018112909335588000_42.2.202.28","doi-asserted-by":"publisher","DOI":"10.1186\/cc12532"},{"key":"2018112909335588000_42.2.202.29","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2843"},{"key":"2018112909335588000_42.2.202.30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00117.2002"},{"key":"2018112909335588000_42.2.202.31","doi-asserted-by":"publisher","DOI":"10.3727\/000000008783907134"},{"key":"2018112909335588000_42.2.202.32","doi-asserted-by":"publisher","DOI":"10.1002\/path.3964"},{"key":"2018112909335588000_42.2.202.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.02.032"},{"key":"2018112909335588000_42.2.202.34","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp097"},{"key":"2018112909335588000_42.2.202.35","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181cdc363"},{"key":"2018112909335588000_42.2.202.36","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880435"},{"key":"2018112909335588000_42.2.202.37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3893203.x"},{"key":"2018112909335588000_42.2.202.38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050515"},{"key":"2018112909335588000_42.2.202.39","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket108"},{"key":"2018112909335588000_42.2.202.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058140"},{"key":"2018112909335588000_42.2.202.41","doi-asserted-by":"publisher","DOI":"10.1159\/000049151"},{"key":"2018112909335588000_42.2.202.42","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwj098"},{"key":"2018112909335588000_42.2.202.43","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwh148"},{"key":"2018112909335588000_42.2.202.44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611259200"},{"key":"2018112909335588000_42.2.202.45","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.7.1189"},{"key":"2018112909335588000_42.2.202.46","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm194"},{"key":"2018112909335588000_42.2.202.47","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.425"},{"key":"2018112909335588000_42.2.202.48","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00429.2007"},{"key":"2018112909335588000_42.2.202.49","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.610"},{"key":"2018112909335588000_42.2.202.50","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp001"},{"key":"2018112909335588000_42.2.202.51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807001200"},{"key":"2018112909335588000_42.2.202.52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204966"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.140568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T12:30:37Z","timestamp":1650803437000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.140568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,1]]},"published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.3899\/jrheum.140568"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.140568","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}