{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:47:45Z","timestamp":1792640865068,"version":"4.5.0"},"reference-count":40,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To identify early echocardiographic abnormalities at the time of diagnosis of polymyositis (PM) and dermatomyositis (DM) and follow the echocardiographic findings during the first 3 months of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We included 30 PM\/DM patients (23\/7) with a mean age of 42.3 \u00b1 1.6 years and without cardiovascular symptoms. Age-matched healthy patients served as controls. Clinical characteristics were recorded. Traditional echocardiography and tissue Doppler imaging (TDI) were performed to measure systolic [ejection fraction, right ventricular fractional area change (RV FAC), lateral and tricuspid annulus s velocities] and diastolic echocardiographic variables (mitral inflow velocities: E, A; deceleration time: DT; lateral and tricuspid annulus e\u2032, a\u2032 velocities, lateral E\/e\u2032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The left and right ventricular systolic dysfunction detected by TDI at the time of the PM\/DM diagnosis improved, and characteristic values at the end of the followup period were comparable to those of the controls (lateral s: 10.6 \u00b1 0.2, 8.7 \u00b1 0.4, 9.6 \u00b1 0.3, 11.3 \u00b1 0.2 cm\/s; RV FAC: 45.2 \u00b1 2.3, 36.9 \u00b1 1.5, 42.2 \u00b1 1.3, 46.9 \u00b1 1.2%; tricuspid s: 13.3 \u00b1 0.2, 9.5 \u00b1 0.4, 10.3 \u00b1 0.3, 11.6 \u00b1 0.5 cm\/s; control, 0, 1, and 3 mos, respectively). Measurements indicated the development of diastolic dysfunction at 3 mos (E\/A: 1.4 \u00b1 0.1, 1.29 \u00b1 0.05, 1.03 \u00b1 0.05, 0.92 \u00b1 0.05; DT: 148.6 \u00b1 3.6, 157.3 \u00b1 5.7, 168.3 \u00b1 6.0, 184.3 \u00b1 6.2 ms; lateral e\u2032: 12.8 \u00b1 0.3, 12.1 \u00b1 0.5, 10.2 \u00b1 0.6, 10.8 \u00b1 0.8 cm\/s; E\/e\u2032: 5.6 \u00b1 0.1, 5.0 \u00b1 0.22, 6.92 \u00b1 0.46, 7.64 \u00b1 0.47; control, 0, 1, and 3 mos, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>TDI is a useful method to detect early cardiac abnormalities complementing the conventional echocardiographic measurements. LV and RV systolic dysfunction found in the acute phase significantly improved during the first 3 months of therapy; however, deterioration of diastolic dysfunction was also observed.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.140626","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T20:44:02Z","timestamp":1417293842000},"page":"272-281","source":"Crossref","is-referenced-by-count":26,"title":["Echocardiographic Abnormalities in New-onset Polymyositis\/dermatomyositis"],"prefix":"10.3899","volume":"42","author":[{"given":"Andrea","family":"P\u00e9ter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szabolcs","family":"Szil\u00e1gyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Faludi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Nagy-Vincze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"\u00c9des","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Dank\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2014,11,29]]},"reference":[{"key":"2018112909335612000_42.2.272.1","unstructured":"Fauci AS Langford CA Harrison TR . 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