{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:46:23Z","timestamp":1792896383160,"version":"4.5.0"},"reference-count":39,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Beh\u00e7et disease (BD) is a multifactorial disease in which infectious agents have been proposed as triggers in genetically predisposed individuals. The aim of our study was to investigate the role of innate immunity receptors, specifically the nucleic acid sensors, in susceptibility to BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy-four tag single nucleotide polymorphisms (tSNP) selected in 9 candidate genes (<jats:italic>DDX58, IFIH1, TLR3, TLR7, TLR8, AIM2, IFI16, ZBP1,<\/jats:italic> and <jats:italic>TLR9<\/jats:italic>) were genotyped in 371 patients and 854 controls. Assays of mRNA expression and allele-specific transcript quantification (ASTQ) were performed in 110 and 50 controls, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients and controls were genotyped and 2 tSNP (rs6940 in <jats:italic>IFI16<\/jats:italic> and rs855873 in <jats:italic>AIM2<\/jats:italic>) were associated with BD. To confirm this association, these tSNP were genotyped in 850 additional controls, and the total cohort was randomly divided into 2 cohorts. The association of these 2 tSNP with the disease remained in both cohorts. One haplotype (rs6940T-rs855873G) was identified as a risk factor (OR 1.41, 95% CI 1.06\u20131.86, p = 0.015), and another (rs6940A-rs855873A) as a protective factor (OR 0.65, 95% CI 0.47\u20130.90, p = 0.009). Samples with the risk haplotype had lower <jats:italic>IFI16<\/jats:italic> expression levels than samples with the protective (0.99 \u00b1 0.29 vs 1.23 \u00b1 0.50, p = 0.022). Consistently, in the ASTQ assays performed with the nonsynonymous rs6940 SNP, the risk allele had lower <jats:italic>IFI16<\/jats:italic> expression levels than the protective (p = 0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our findings suggest association of <jats:italic>IFI16<\/jats:italic>, a cytosolic sensor of dsDNA and mediator of the AIM2 inflammasome-dependent pathway, in susceptibility to BD. Differences genetically determined in the levels of this molecule could be the cause of this association.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.140949","type":"journal-article","created":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T20:13:25Z","timestamp":1422821605000},"page":"695-701","source":"Crossref","is-referenced-by-count":21,"title":["Variants of the <i>IFI16<\/i> Gene Affecting the Levels of Expression of mRNA Are Associated with Susceptibility to Beh\u00e7et 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