{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:38:34Z","timestamp":1773898714007,"version":"3.50.1"},"reference-count":24,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To describe the expression and diagnostic use of 14-3-3\u03b7 autoantibodies in early rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>14-3-3\u03b7 autoantibody levels were measured using an electrochemiluminescent multiplexed assay in 500 subjects (114 disease-modifying antirheumatic drug-naive patients with early RA, 135 with established RA, 55 healthy, 70 autoimmune, and 126 other non-RA arthropathy controls). 14-3-3\u03b7 protein levels were determined in an earlier analysis. Two-tailed Student t tests and Mann-Whitney U tests compared differences among groups. Receiver-operator characteristic (ROC) curves were generated and diagnostic performance was estimated by area under the curve (AUC), as well as specificity, sensitivity, and likelihood ratios (LR) for optimal cutoffs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Median serum 14-3-3\u03b7 autoantibody concentrations were significantly higher (p &lt; 0.0001) in patients with early RA (525 U\/ml) when compared with healthy controls (235 U\/ml), disease controls (274 U\/ml), autoimmune disease controls (274 U\/ml), patients with osteoarthritis (259 U\/ml), and all controls (265 U\/ml). ROC curve analysis comparing early RA with healthy controls demonstrated a significant (p &lt; 0.0001) AUC of 0.90 (95% CI 0.85\u20130.95). At an optimal cutoff of \u2265 380 U\/ml, the ROC curve yielded a sensitivity of 73%, a specificity of 91%, and a positive LR of 8.0. Adding 14-3-3\u03b7 autoantibodies to 14-3-3\u03b7 protein positivity enhanced the identification of patients with early RA from 59% to 90%; addition of 14-3-3\u03b7 autoantibodies to anticitrullinated protein antibodies (ACPA) and\/or rheumatoid factor (RF) increased identification from 72% to 92%. Seventy-two percent of RF- and ACPA-seronegative patients were positive for 14-3-3\u03b7 autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>14-3-3\u03b7 autoantibodies, alone and in combination with the 14-3-3\u03b7 protein, RF, and\/or ACPA identified most patients with early RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.141385","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T01:10:43Z","timestamp":1437009043000},"page":"1587-1594","source":"Crossref","is-referenced-by-count":30,"title":["14-3-3\u03b7 Autoantibodies: Diagnostic Use in Early Rheumatoid Arthritis"],"prefix":"10.3899","volume":"42","author":[{"given":"Walter P.","family":"Maksymowych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Boire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirkjan","family":"van 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