{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:39:29Z","timestamp":1790383169120,"version":"4.1.0"},"reference-count":26,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate the effect of anti-tumor necrosis factor (TNF) therapy on bone mineral density (BMD) in patients with active ankylosing spondylitis (AS) with low BMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Eighty-nine patients with active AS with low BMD were randomly divided into either a study group or a control group. The study group received etanercept (50 mg\/week) or adalimumab (40 mg\/2 week) subcutaneously for 1 year. BMD of lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry, and bone turnover markers serum C telopeptide of type-I collagen (sCTX) and serum procollagen type-I N propeptide (PINP) were detected by ELISA at baseline and at end of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>After 1 year, compared with baseline, there was a significant increase in spine and femoral neck BMD by a mean \u00b1 SD of 14.9% \u00b1 15.6% (p &lt; 0.0001) and 4.7% \u00b1 7.9% (p &lt; 0.0001) in the study group. In the control group, there was a significant decrease in spine and femoral neck BMD by a mean \u00b1 SD of \u22128.6% \u00b1 9.7% (p &lt; 0.0001) and \u22129.8% \u00b1 11.5% (p &lt; 0.0001). Compared with baseline, sCTX was significantly decreased in the study group (\u221240% at 1 yr, p &lt; 0.0001), but bone-specific alkaline phosphatase and PINP increased (45.6%, p &lt; 0.0001 and 30.8%, p &lt; 0.0001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In patients with active AS with low BMD, the spine and femoral neck BMD increased after anti-TNF therapy for 1 year, and it was accompanied by a significant decrease in bone resorption markers and an increase in bone formation markers.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150019","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T21:12:55Z","timestamp":1434402775000},"page":"1413-1417","source":"Crossref","is-referenced-by-count":13,"title":["Anti-tumor Necrosis Factor Therapy Increased Spine and Femoral Neck Bone Mineral Density of Patients with Active Ankylosing Spondylitis with Low Bone Mineral Density"],"prefix":"10.3899","volume":"42","author":[{"given":"Haibo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"2018112909343101000_42.8.1413.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0172-1"},{"key":"2018112909343101000_42.8.1413.2","first-page":"1511","article-title":"How should clinicians manage osteoporosis in ankylosing spondylitis?","volume":"29","author":"Bessant","year":"2002","journal-title":"J Rheumatol"},{"key":"2018112909343101000_42.8.1413.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.1.85"},{"key":"2018112909343101000_42.8.1413.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2018-0"},{"key":"2018112909343101000_42.8.1413.5","doi-asserted-by":"publisher","DOI":"10.1186\/ar3833"},{"key":"2018112909343101000_42.8.1413.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2066-9"},{"key":"2018112909343101000_42.8.1413.7","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120316"},{"key":"2018112909343101000_42.8.1413.8","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000053"},{"key":"2018112909343101000_42.8.1413.9","doi-asserted-by":"publisher","DOI":"10.1186\/ar3823"},{"key":"2018112909343101000_42.8.1413.10","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121417"},{"key":"2018112909343101000_42.8.1413.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.008"},{"key":"2018112909343101000_42.8.1413.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2018112909343101000_42.8.1413.13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.040758"},{"key":"2018112909343101000_42.8.1413.14","unstructured":"The International Society for Clinical Densitometry . 2013 ISCD official positions \u2013 adult. 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