{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:01:19Z","timestamp":1790949679701,"version":"4.1.0"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate the effects of changing inflammation on lipid levels in ankylosing spondylitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In a cohort of 230 patients, lipid levels were measured at baseline and after 52 weeks of treatment with tumor necrosis factor-\u03b1\u2013blocking agents (anti-TNF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Total cholesterol (TC; +4.6%), low-density lipoprotein cholesterol (+4.3%), and high-density lipoprotein cholesterol (HDL-C; +3.7%) increased upon treatment. Changes were most evident in patients with substantial reduction in inflammatory levels (TC +8.2% vs +1.6% and HDL-C +8.3% vs +2.2% in patients with C-reactive protein \u2265 10 mg\/l normalizing upon treatment vs CRP &lt; 10 mg\/l throughout treatment period).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Anti-TNF therapy results in lipid changes mostly when inflammation is appreciably modified.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150193","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T21:23:46Z","timestamp":1441142626000},"page":"1842-1845","source":"Crossref","is-referenced-by-count":22,"title":["Reduction of Inflammation Drives Lipid Changes in Ankylosing Spondylitis"],"prefix":"10.3899","volume":"42","author":[{"given":"Sjoerd C.","family":"Heslinga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike 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