{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:47Z","timestamp":1761513707380},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess the responsiveness of high- and low-field extremity magnetic resonance imaging (MRI) variables at multiple timepoints in the first 12 weeks post-antitumor necrosis factor (anti-TNF) therapy initiation in patients with psoriatic arthritis (PsA) and active dactylitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Twelve patients with active PsA and clinical evidence of dactylitis involving at least 1 digit were recruited. Patients underwent sequential high-field conventional (1.5 Tesla) and extremity low-field MRI (0.2 Tesla) of the affected hand or foot, pre- and postgadolinium at baseline (pre-TNF), 2 weeks (post-TNF), 6 weeks, and 12 weeks. A blinded observer scored all images on 2 occasions using the PsA MRI scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Eleven patients completed the study, but only 6 patients completed all high-field and low-field MRI assessments. MRI scores demonstrated rapid response to TNF inhibition with score reduction in tenosynovitis, synovitis, and osteitis at 2 weeks. Intraobserver reliability was good to excellent for all variables. High-field MRI demonstrated greater sensitivity to tenosynovitis, synovitis, and osteitis and greater responsiveness to change posttreatment. Treatment responses were maintained to 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study demonstrates the use of MRI in detecting early response to biologic therapy. MRI variables of tenosynovitis, synovitis, and osteitis demonstrated responsiveness posttherapy with high-field scores more responsive to change than low-field scores.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150347","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T21:48:17Z","timestamp":1444945697000},"page":"75-80","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Magnetic Resonance Imaging Responsiveness in Active Psoriatic Arthritis at Multiple Timepoints during the First 12 Weeks of Antitumor Necrosis Factor Therapy"],"prefix":"10.3899","volume":"43","author":[{"given":"Marie","family":"Feletar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"2018112909351264000_43.1.75.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032318"},{"key":"2018112909351264000_43.1.75.2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090351"},{"key":"2018112909351264000_43.1.75.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068361"},{"key":"2018112909351264000_43.1.75.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.21445"},{"key":"2018112909351264000_43.1.75.5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200308"},{"key":"2018112909351264000_43.1.75.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.121"},{"key":"2018112909351264000_43.1.75.7","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090352"},{"key":"2018112909351264000_43.1.75.8","first-page":"1745","article-title":"Development of an assessment tool for dactylitis in patients with psoriatic arthritis","volume":"32","author":"Helliwell","year":"2005","journal-title":"J Rheumatol"},{"key":"2018112909351264000_43.1.75.9","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110420"},{"key":"2018112909351264000_43.1.75.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100149"},{"key":"2018112909351264000_43.1.75.11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063818"},{"key":"2018112909351264000_43.1.75.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.10671"},{"key":"2018112909351264000_43.1.75.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.9.854"},{"key":"2018112909351264000_43.1.75.14","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.783105"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.150347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:01:44Z","timestamp":1543500104000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.150347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,15]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.3899\/jrheum.150347"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.150347","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,15]]}}}