{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:24:23Z","timestamp":1768825463604,"version":"3.49.0"},"reference-count":40,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To estimate the longterm humoral response of an antipneumococcal polysaccharide vaccine (PPSV23) in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), or inflammatory bowel disease (IBD)-associated spondyloarthropathy (SpA), and the effect of demographic and clinical factors and treatment on the longterm efficacy of the vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A total of 145 consecutive patients treated with biologics [tumor necrosis factor-\u03b1 (TNF-\u03b1) or interleukin 6 (IL-6) receptor inhibitors] or methotrexate (MTX) participated in this study. Fifteen were excluded because of absent information regarding their vaccination status (n = 9) or because of technical problems in obtaining their serum sample (n = 6). They were diagnosed with RA (n = 63, 48.5%), PsA (n = 29, 22.3%), AS (n = 28, 21.5%), or IBD-associated SpA (n = 3, 2.3%). Their mean age was 54.6 years, and 61.5% were women. Data were collected on the timing of vaccination, demographic and clinical characteristics, and treatment, and patients\u2019 serum antipneumococcal antibody levels were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Two-thirds of the patients (67.7%) had received PPSV23 45 months (mean) earlier. Treatment included TNF-\u03b1 inhibitors (73.9%), IL-6 receptor inhibitors (13.1%), or MTX without a biological treatment (13%). The uptake of vaccination was significantly higher in the older population (&gt; 65 yrs). Vaccinated patients had significantly higher antibody levels compared with vaccine-naive patients. The antibody levels had been preserved after 10 years. MTX use, but not biologics, was associated with significantly lower antibody levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The longterm efficacy of the PPSV23 vaccination seems to be preserved among patients with RA, PsA, AS, and IBD-associated SpA for at least 10 years. Efficacy is slightly impaired by MTX, but it is not affected by biologics. These findings suggest that revaccination after 5 years might not be needed for all, and testing the antibody titers should be considered to identify those who may benefit from revaccination.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150397","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T17:18:46Z","timestamp":1452964726000},"page":"267-272","source":"Crossref","is-referenced-by-count":27,"title":["Longterm Efficacy of an Antipneumococcal Polysaccharide Vaccine among Patients with Autoimmune Inflammatory Rheumatic Diseases"],"prefix":"10.3899","volume":"43","author":[{"given":"Adi","family":"Broyde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Arad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Madar-Balakirski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphna","family":"Paran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Levartovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Wigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Caspi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Elkayam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"2018112909351950000_43.2.267.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137216"},{"key":"2018112909351950000_43.2.267.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0441-9"},{"key":"2018112909351950000_43.2.267.3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306071919"},{"key":"2018112909351950000_43.2.267.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.10524"},{"key":"2018112909351950000_43.2.267.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370408"},{"key":"2018112909351950000_43.2.267.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091181.93122.55"},{"key":"2018112909351950000_43.2.267.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"2018112909351950000_43.2.267.8","first-page":"1204","article-title":"Causes of death and poor survival prognostic factors in Thai patients with systemic sclerosis","volume":"85","author":"Ruangjutipopan","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"2018112909351950000_43.2.267.9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"2018112909351950000_43.2.267.10","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J"},{"key":"2018112909351950000_43.2.267.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.21083"},{"key":"2018112909351950000_43.2.267.12","first-page":"1","article-title":"Prevention of pneumococcal disease: recommendations of the Advisory committee on immunization practices (ACIP)","volume":"46","year":"1997","journal-title":"MMWR Recomm Rep"},{"key":"2018112909351950000_43.2.267.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371404"},{"key":"2018112909351950000_43.2.267.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301073280104"},{"key":"2018112909351950000_43.2.267.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021334"},{"key":"2018112909351950000_43.2.267.16","doi-asserted-by":"publisher","DOI":"10.1086\/338043"},{"key":"2018112909351950000_43.2.267.17","first-page":"1356","article-title":"Pneumococcal vaccine response in psoriatic arthritis patients during treatment with etanercept","volume":"31","author":"Mease","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909351950000_43.2.267.18","first-page":"952","article-title":"Response to pneumococcal vaccine in patients with early rheumatoid arthritis receiving infliximab plus methotrexate or methotrexate alone","volume":"34","author":"Visvanathan","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909351950000_43.2.267.19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei193"},{"key":"2018112909351950000_43.2.267.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.semarthrit.2003.10.003"},{"key":"2018112909351950000_43.2.267.21","doi-asserted-by":"publisher","DOI":"10.1002\/art.25034"},{"key":"2018112909351950000_43.2.267.22","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198705000-00001"},{"key":"2018112909351950000_43.2.267.23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510150060030"},{"key":"2018112909351950000_43.2.267.24","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000422.pub2"},{"key":"2018112909351950000_43.2.267.25","first-page":"816","article-title":"Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2018112909351950000_43.2.267.26","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144451"},{"key":"2018112909351950000_43.2.267.27","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.5.341"},{"key":"2018112909351950000_43.2.267.28","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"2018112909351950000_43.2.267.29","unstructured":"Gofton JP . Report from the subcommittee on diagnostic criteria for ankylosing spondylitis. In: Bennett PH Wood HN , eds. Population studies of the rheumatic diseases; 1966. New York: Excerpta Medica; 1966:314\u20136, 456\u20137."},{"key":"2018112909351950000_43.2.267.30","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.10.2.202-207.2003"},{"key":"2018112909351950000_43.2.267.31","doi-asserted-by":"publisher","DOI":"10.1086\/649839"},{"key":"2018112909351950000_43.2.267.32","doi-asserted-by":"publisher","DOI":"10.1086\/651131"},{"key":"2018112909351950000_43.2.267.33","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702007000300005"},{"key":"2018112909351950000_43.2.267.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.07.024"},{"key":"2018112909351950000_43.2.267.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.052"},{"key":"2018112909351950000_43.2.267.36","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis513"},{"key":"2018112909351950000_43.2.267.37","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268897007978"},{"key":"2018112909351950000_43.2.267.38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/TP.0b013e318250fc8c","article-title":"Long-term response to vaccination against pneumococcal antigens in kidney transplant recipients","volume":"94","author":"Lindemann","year":"2012","journal-title":"Transplantation"},{"key":"2018112909351950000_43.2.267.39","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0959-7"},{"key":"2018112909351950000_43.2.267.40","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.080734"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.150397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T19:01:12Z","timestamp":1543518072000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.150397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,2,1]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3899\/jrheum.150397"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.150397","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]}}}