{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:56:25Z","timestamp":1790794585157,"version":"4.1.0"},"reference-count":38,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>Concerns have been raised about nonadherence behavior among patients with chronic inflammatory rheumatic diseases (CIRD) receiving biologics. This nonadherence may be caused by various factors. The main objective was to explain why patients discontinue their biologics of their own accord.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>A quantitative and descriptive study was performed using a self-report questionnaire that was sent through the Internet to members of different patient associations. Sociodemographic data, medical and therapeutic history, management of biologic administration, previous experiences, and patients\u2019 beliefs and perceptions about treatment efficacy and side effects were studied to explain self-discontinuation (SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>A total of 581 patients answered the questionnaire between June 16, 2012, and July 4, 2012, including patients with ankylosing spondylitis (351\/581, 60.4%), rheumatoid arthritis (196\/581, 33.7%), psoriatic arthritis (30\/581, 5.2%), and other CIRD (4\/581, 0.7%). More than 1000 different biologics were described by the 581 patients, with a median of 2 lines per patient. Eighty-six patients discontinued their biologics of their own accord (14.8%). In a multivariate analysis, factors that were significantly related to SD were low level of pain, more than 1 line of biologics tried, self-administration of biologics, negative beliefs about the treatment, and a lack of medical and social support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Five predictive factors of this SD were identified, which should be assessed in routine with patients with CIRD receiving biologic treatment: pain, treatment history, self-administration of injections, negative beliefs about treatment, and a lack of perceived medical and social support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.150414","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T21:54:01Z","timestamp":1455573241000},"page":"724-730","source":"Crossref","is-referenced-by-count":52,"title":["Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients\u2019 Adherence Using a Self-report Questionnaire"],"prefix":"10.3899","volume":"43","author":[{"given":"Anne-Laure","family":"Betegnie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gauchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Roustit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Baudrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Bedouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Allenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"2018112909353146000_43.4.724.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60784-3"},{"key":"2018112909353146000_43.4.724.2","first-page":"210","article-title":"Emerging therapeutics for rheumatoid arthritis","volume":"66","author":"Bingham","year":"2008","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"2018112909353146000_43.4.724.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200354"},{"key":"2018112909353146000_43.4.724.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087262"},{"key":"2018112909353146000_43.4.724.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.124446"},{"key":"2018112909353146000_43.4.724.6","first-page":"958","article-title":"Anti-TNF therapy of ankylosing spondylitis in clinical practice. Results from the Czech national registry ATTRA","volume":"27","author":"Pavelka","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909353146000_43.4.724.7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq326"},{"key":"2018112909353146000_43.4.724.8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200302"},{"key":"2018112909353146000_43.4.724.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201933"},{"key":"2018112909353146000_43.4.724.10","doi-asserted-by":"publisher","DOI":"10.1186\/ar2670"},{"key":"2018112909353146000_43.4.724.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0621-9"},{"key":"2018112909353146000_43.4.724.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00213.x"},{"key":"2018112909353146000_43.4.724.13","first-page":"39","article-title":"Patient medication adherence: the forgotten aspect of biologics","volume":"6","author":"Goldberg","year":"2009","journal-title":"Biotechnol Healthc"},{"key":"2018112909353146000_43.4.724.14","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2010.510508"},{"key":"2018112909353146000_43.4.724.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.06.001"},{"key":"2018112909353146000_43.4.724.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126532"},{"key":"2018112909353146000_43.4.724.17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu358"},{"key":"2018112909353146000_43.4.724.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00205.x"},{"key":"2018112909353146000_43.4.724.19","doi-asserted-by":"publisher","DOI":"10.1185\/03007990902896386"},{"key":"2018112909353146000_43.4.724.20","doi-asserted-by":"publisher","DOI":"10.1002\/art.24114"},{"key":"2018112909353146000_43.4.724.21","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000241107.15133.54"},{"issue":"Suppl","key":"2018112909353146000_43.4.724.22","first-page":"S136","article-title":"Treatment compliance and dosage administration among rheumatoid arthritis patients receiving infliximab, etanercept, or methotrexate","volume":"9","author":"Harley","year":"2003","journal-title":"Am J Manag Care"},{"key":"2018112909353146000_43.4.724.23","unstructured":"Betegnie AL Lehmann A Baudrant M Roustit M Bedouch P Grange L [Adherence to biotherapy in inflammatory rheumatism: identifying ways to better support the patient]. [Article in French. Internet. Accessed January 13, 2016.] Available from: www.freepaperdownload.us\/1764\/Article5569661.htm"},{"key":"2018112909353146000_43.4.724.24","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9865-x"},{"key":"2018112909353146000_43.4.724.25","unstructured":"Kline P . An easy guide to factor analysis. London: Routledge; 1994."},{"key":"2018112909353146000_43.4.724.26","first-page":"207","article-title":"The fallacy of five factors in the personality sphere","volume":"8","author":"Cattell","year":"1995","journal-title":"Psychologist"},{"key":"2018112909353146000_43.4.724.27","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0037-5"},{"key":"2018112909353146000_43.4.724.28","doi-asserted-by":"publisher","DOI":"10.1159\/000337422"},{"key":"2018112909353146000_43.4.724.29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768986"},{"key":"2018112909353146000_43.4.724.30","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000173016.87612.4b"},{"key":"2018112909353146000_43.4.724.31","doi-asserted-by":"publisher","DOI":"10.1002\/art.24463"},{"key":"2018112909353146000_43.4.724.32","first-page":"129","article-title":"Understanding compliance issues for daily self-injectable treatment in ambulatory care settings","volume":"2","author":"Brod","year":"2008","journal-title":"Patient Prefer Adherence"},{"key":"2018112909353146000_43.4.724.33","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0816-6"},{"key":"2018112909353146000_43.4.724.34","doi-asserted-by":"publisher","DOI":"10.1186\/ar2084"},{"key":"2018112909353146000_43.4.724.35","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-007-0153-9"},{"key":"2018112909353146000_43.4.724.36","doi-asserted-by":"publisher","DOI":"10.1002\/art.21071"},{"key":"2018112909353146000_43.4.724.37","first-page":"44","article-title":"Patient compliance in rheumatoid arthritis, polymyalgia rheumatica, and gout","volume":"30","author":"de Klerk","year":"2003","journal-title":"J Rheumatol"},{"key":"2018112909353146000_43.4.724.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-3991(98)00087-1"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.150414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:04:21Z","timestamp":1543500261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.150414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,1]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.3899\/jrheum.150414"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.150414","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,15]]}}}