{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T11:58:32Z","timestamp":1720526312553},"reference-count":19,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess monocytic expression and ratio of angiotensin and endothelin receptors in systemic sclerosis (SSc) and their functional relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Receptor expression was measured by flow cytometry. Chemokine ligand 18 (CCL18) concentration in supernatants of peripheral blood mononuclear cells stimulated with immunoglobulin G was measured by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Monocytes of patients with SSc presented an increased angiotensin II Type 1 receptor (AT1R)\/AT2R ratio compared with those of healthy donors. Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 Type A receptor (ETAR)\/ETBR ratio. High AT1R\/AT2R, but low ETAR\/ETBR ratios corresponded to higher CCL18 secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Altered angiotensin and endothelin receptor ratios observed in SSc influence autoantibody-mediated effects such as secretion of profibrotic CCL18.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150474","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T17:18:46Z","timestamp":1452964726000},"page":"587-591","source":"Crossref","is-referenced-by-count":15,"title":["Monocytic Angiotensin and Endothelin Receptor Imbalance Modulate Secretion of the Profibrotic Chemokine Ligand 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