{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:49:32Z","timestamp":1778942972508,"version":"3.51.4"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine the relationship between tophus, erosion and bone remodeling factors in gout.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Computed tomography bone erosion and circulating bone factors were measured in adults with tophaceous gout. Multiple regression modeling and path analysis were used to determine predictors of erosion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Tophus number, M\u0101ori or Pacific ethnicity, creatinine, receptor activator of nuclear factor-\u03baB ligand (RANKL), osteoprotegerin (OPG), and sclerostin were independently associated with erosion. Path analysis showed a direct effect of tophus number on erosion, partially mediated through OPG, RANKL, and sclerostin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Tophus number is strongly associated with bone erosion in gout. Circulating RANKL, OPG, and sclerostin are potential mediators of tophus-related erosion.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.150738","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T12:18:46Z","timestamp":1452946726000},"page":"445-449","source":"Crossref","is-referenced-by-count":14,"title":["Path Analysis Identifies Receptor Activator of Nuclear Factor-\u03baB Ligand, Osteoprotegerin, and Sclerostin as Potential Mediators of the Tophus-bone Erosion Relationship in Gout"],"prefix":"10.3899","volume":"43","author":[{"given":"Ashika","family":"Chhana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opetaia","family":"Aati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen 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