{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:46:48Z","timestamp":1762004808185},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Objective.<\/jats:title>To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.<\/jats:p><\/jats:sec>Methods.<\/jats:title>There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5<\/jats:italic>-rs10488631,STAT4<\/jats:italic>-rs3821236,CD247<\/jats:italic>-rs2056626,DNASE1L3<\/jats:italic>-rs35677470,IL12A<\/jats:italic>-rs77583790, andATG5<\/jats:italic>-rs9373839). Association tests were conducted to identify possible associations.<\/jats:p><\/jats:sec>Results.<\/jats:title>Except forATG5<\/jats:italic>, all the analyzed genes showed either significant associations (IRF5<\/jats:italic>: p = 1.32E\u201305, OR 1.76;CD247<\/jats:italic>: p = 2.20E\u201303, OR 0.75) or trends of association (STAT4<\/jats:italic>: p = 0.066, OR 1.21;IL12A<\/jats:italic>: p = 0.079, OR 4.07;DNASE1L3<\/jats:italic>: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.<\/jats:p><\/jats:sec>Conclusion.<\/jats:title>The genetic component of SSc seems to be similar between Turks and Europeans.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160045","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:12:56Z","timestamp":1462147976000},"page":"1376-1379","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of Systemic Sclerosis-associated Genes in a Turkish Population"],"prefix":"10.3899","volume":"43","author":[{"given":"F. 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