{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:18:32Z","timestamp":1772497112904,"version":"3.50.1"},"reference-count":12,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess toreforant (selective histamine H<jats:sub>4<\/jats:sub>receptor antagonist) in active rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In a phase IIa, double-blind, placebo-controlled test, 86 patients were randomized (2:1) to once-daily toreforant 100 mg or placebo for 12 weeks. In phase IIb, double-blind, placebo-controlled, dose-range\u2013finding evaluations, 272 patients were randomized (1:1:1:1) to once-daily placebo or toreforant 3\/10\/30 mg. Primary efficacy endpoints for both studies were Week 12 changes in 28-joint Disease Activity Score\u2013C-reactive protein (DAS28-CRP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Phase IIa testing was terminated prematurely (patient fatality; secondary hemophagocytic lymphohistiocytosis). Posthoc analyses indicated toreforant 100 mg\/day reduced RA signs\/symptoms through Week 12. Phase IIb testing, however, showed no significant Week 12 improvement in DAS28-CRP with toreforant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Toreforant was not effective in phase IIb testing.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160164","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T01:59:01Z","timestamp":1468634341000},"page":"1637-1642","source":"Crossref","is-referenced-by-count":20,"title":["Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies"],"prefix":"10.3899","volume":"43","author":[{"given":"Robin 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