{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:46:36Z","timestamp":1788997596745,"version":"build-2803163510"},"reference-count":24,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>The term \u201cinvalidation\u201d refers to the patients\u2019 perception that their medical condition is not recognized by the social environment. Invalidation can be a major issue in patients\u2019 lives, adding a significant burden to symptoms and limitations while increasing the risk of physical and psychological disability. In this study in patients with rheumatic diseases, we investigated the relationship between invalidation and sociodemographic, clinical, psychological, and personality characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>This international cross-sectional study included 562 adults with rheumatoid arthritis (n = 124), spondyloarthritis (n = 85), systemic lupus erythematosus (n = 112), or fibromyalgia (FM; n = 241). Assessed were the family and health professionals subscales of the Illness Invalidation Inventory (3*I), happiness (Subjective Happiness Scale), personality (Ten-Item Personality Inventory), pain, and loneliness (numerical rating scales). Univariate and multivariate analyses were used to test different models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Invalidation occurred in all rheumatic diseases, but patients with FM reported the most invalidation. Including all correlated variables in the multivariate model, pain remained as a determinant of invalidation by health professionals, but not by family. Regarding psychological variables, loneliness remained as a determinant of invalidation by family, but not by health professionals. FM and low levels of happiness, agreeableness, and conscientiousness were associated with invalidation while taking account of other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Invalidation occurs in all rheumatic diseases and patients with FM experience the most invalidation. Psychological factors (happiness, agreeableness, and conscientiousness), loneliness, and pain intensity are associated with invalidation, irrespective of the rheumatic disease and may deserve dedicated interventions.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160559","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T20:25:25Z","timestamp":1487190325000},"page":"512-518","source":"Crossref","is-referenced-by-count":42,"title":["Invalidation in Patients with Rheumatic Diseases: Clinical and Psychological Framework"],"prefix":"10.3899","volume":"44","author":[{"given":"Mariana Galante","family":"Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Kool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinie","family":"Geenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ant\u00f3nio P.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"2018112909371160000_44.4.512.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24922"},{"key":"2018112909371160000_44.4.512.2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201807"},{"key":"2018112909371160000_44.4.512.3","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.98.2.310"},{"key":"2018112909371160000_44.4.512.4","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.46.5.1097"},{"key":"2018112909371160000_44.4.512.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.06.024"},{"key":"2018112909371160000_44.4.512.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00544-3"},{"key":"2018112909371160000_44.4.512.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2010.12.032"},{"key":"2018112909371160000_44.4.512.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123224"},{"key":"2018112909371160000_44.4.512.9","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.2011.606434"},{"key":"2018112909371160000_44.4.512.10","doi-asserted-by":"publisher","DOI":"10.1037\/a0015952"},{"key":"2018112909371160000_44.4.512.11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11205-010-9769-2","article-title":"Psychometric properties of a Portuguese version of the Subjective Happiness Scale","volume":"105","author":"Spagnoli","year":"2012","journal-title":"Social Indicators Res"},{"key":"2018112909371160000_44.4.512.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-6566(03)00046-1"},{"issue":"Suppl 69","key":"2018112909371160000_44.4.512.13","first-page":"S63","article-title":"Patient and spouse appraisals of health status in rheumatoid arthritis and fibromyalgia: discrepancies and associations with invalidation","volume":"29","author":"Kool","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909371160000_44.4.512.14","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.48.1.26"},{"key":"2018112909371160000_44.4.512.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.05.010"},{"key":"2018112909371160000_44.4.512.16","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.55.1.5"},{"key":"2018112909371160000_44.4.512.17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.54.101601.145056"},{"key":"2018112909371160000_44.4.512.18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10902-005-4754-1","article-title":"How do people pursue happiness?: relating personality, happiness-increasing strategies, and well-being","volume":"7","author":"Tkach","year":"2006","journal-title":"J Happiness Stud"},{"key":"2018112909371160000_44.4.512.19","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009305"},{"key":"2018112909371160000_44.4.512.20","first-page":"584573","article-title":"The prevalence of fibromyalgia in other chronic pain conditions","volume":"2012","author":"Yunus","year":"2012","journal-title":"Pain Res Treat"},{"key":"2018112909371160000_44.4.512.21","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-010-9210-8"},{"key":"2018112909371160000_44.4.512.22","doi-asserted-by":"crossref","unstructured":"Hayes SC Strosahl KD Wilson KG . Acceptance and commitment therapy. 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