{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:13:09Z","timestamp":1769170389305,"version":"3.49.0"},"reference-count":49,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To synthesize descriptions of periarticular findings at the metacarpophalangeal (MCP) and wrist joints in different types of arthritis and in the normal state imaged by high-resolution peripheral quantitative computed tomography (HR-pQCT); to assemble the literature reporting on the ability of HR-pQCT to detect findings relative to other imaging modalities; and to collate results on the reproducibility of image interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A systematic literature review was performed using terms for HR-pQCT and MCP or wrist joints using medical literature databases and conference abstracts. Any study describing predefined pathology findings, comparison to another radiographic technique, or a measure of reproducibility was included with no limitation by disease state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>We identified 44 studies meeting inclusion criteria from the 1901 articles identified by our search. All 44 reported on pathology findings, including erosions (n = 31), bone microarchitecture (n = 10) and bone mineral density (n = 10) variables, joint space evaluation (n = 7), or osteophyte characterization (n = 7). Seventeen of the studies compared HR-pQCT findings to either plain radiography (n = 9), ultrasound (n = 4), magnetic resonance imaging (n = 5), or microcomputed tomography (n = 2), with HR-pQCT having high sensitivity for erosion detection. Twenty-four studies included an assessment of reproducibility with good to excellent metrics, and highlighting the critical importance of positioning when assessing joint space variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Despite high sensitivity for erosion detection and good reproducibility, more research is required to determine where HR-pQCT can be applied to enhance our understanding of periarticular bone changes in a variety of arthritis conditions.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160647","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T17:33:39Z","timestamp":1475516019000},"page":"1921-1934","source":"Crossref","is-referenced-by-count":19,"title":["High-resolution Peripheral Quantitative Computed Tomography Imaging in the Assessment of Periarticular Bone of Metacarpophalangeal and Wrist Joints"],"prefix":"10.3899","volume":"43","author":[{"given":"Sujay","family":"Nagaraj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Finzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn S.","family":"Stok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Barnabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the SPECTRA Collaboration","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"2018112909361649000_43.10.1921.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.145"},{"key":"2018112909361649000_43.10.1921.2","first-page":"256","article-title":"Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning","volume":"32","author":"Perry","year":"2005","journal-title":"J Rheumatol"},{"key":"2018112909361649000_43.10.1921.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.23"},{"key":"2018112909361649000_43.10.1921.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0140-9"},{"key":"2018112909361649000_43.10.1921.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120218"},{"key":"2018112909361649000_43.10.1921.6","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12495"},{"key":"2018112909361649000_43.10.1921.7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev031"},{"key":"2018112909361649000_43.10.1921.8","first-page":"1335","article-title":"Quantified differences in erosion number and size in the first year of inflammatory arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)","volume":"42","author":"Tom","year":"2015","journal-title":"J Rheumatol"},{"key":"2018112909361649000_43.10.1921.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev256"},{"key":"2018112909361649000_43.10.1921.10","doi-asserted-by":"crossref","unstructured":"Yang H Yu A Burghardt AJ Virayavanich W Link TM Imboden JB Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution-peripheral quantitative computed tomography. 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