{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:44:09Z","timestamp":1782909849851,"version":"3.54.5"},"reference-count":41,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Whether widespread pain (WSP) affects the risk of developing knee pain or knee osteoarthritis (OA) is unknown and could enhance understanding of pain mechanisms in OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Subjects from the Multicenter OA (MOST) study, a US National Institutes of Health\u2013funded prospective cohort of older adults with or at risk of knee OA, were characterized regarding WSP, defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, excluding knee pain at 60 months (baseline). Followup occurred 2 years later. We assessed the relation of WSP to odds of knee pain worsening (\u2265 2-point increase in the Western Ontario and McMaster Universities Arthritis Index pain subscale) using logistic regression, and to odds of incident radiographic knee OA (ROA; Kellgren-Lawrence arthritis scale \u2265 grade 2 of either knee among those free of ROA at baseline) and incident consistent frequent knee pain (CFKP; knee pain on most days during the past month among participants free of knee pain at baseline) in 1 or both knees using multinomial regression adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There were 1752 participants available for analysis [mean age (SD) 67.0 yrs (7.7), body mass index 30.5 kg\/m<jats:sup>2<\/jats:sup>(5.9), 59% women]. Baseline presence of WSP was not associated with worsened knee pain (adjusted OR 1.15, 95% CI 0.89\u20131.48, p = 0.30), ROA (adjusted OR 0.86, 95% CI 0.46\u20131.63, p = 0.65), or incident CFKP (adjusted OR 1.69, 95% CI 0.96\u20132.96, p = 0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>WSP was not significantly associated with worsening knee pain, incident ROA, or CFKP. Development of knee pain and ROA does not appear to be influenced by underlying WSP.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160853","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T01:20:29Z","timestamp":1488417629000},"page":"493-498","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Widespread Pain on Knee Pain Worsening, Incident Knee Osteoarthritis (OA), and Incident Knee Pain: The Multicenter OA (MOST) Study"],"prefix":"10.3899","volume":"44","author":[{"given":"Lisa C.","family":"Carlesso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Frey-Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Nevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2018112909371144000_44.4.493.1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.3.351"},{"key":"2018112909371144000_44.4.493.2","first-page":"2271","article-title":"Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991\u201394","volume":"33","author":"Dillon","year":"2006","journal-title":"J Rheumatol"},{"key":"2018112909371144000_44.4.493.3","first-page":"172","article-title":"Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project","volume":"34","author":"Jordan","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909371144000_44.4.493.4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/art.38284","article-title":"Predictors of new-onset widespread pain in older adults: results from a population-based prospective cohort study in the UK","volume":"66","author":"McBeth","year":"2014","journal-title":"Arthritis Rheum"},{"key":"2018112909371144000_44.4.493.5","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100385"},{"key":"2018112909371144000_44.4.493.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.001"},{"key":"2018112909371144000_44.4.493.7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu240"},{"key":"2018112909371144000_44.4.493.8","first-page":"1341","article-title":"Is chronic widespread pain a predictor of all-cause morbidity? 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