{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:18:52Z","timestamp":1777141132616,"version":"3.51.4"},"reference-count":28,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity\/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) &gt; 3% vs \u2264 3%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Using the Corrona PsA\/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged \u2265 18 years with BSA &gt; 3% versus \u2264 3%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA &gt; 3%; n = 789, BSA \u2264 3%). After adjusting for potential confounding variables, patients with BSA &gt; 3% versus \u2264 3% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 \u00d7 10<jats:sup>\u22128<\/jats:sup>, p = 0.002, and p = 1.21 \u00d7 10<jats:sup>\u22127<\/jats:sup>, respectively), were 1.7\u00d7 more likely not to be in modified MDA (95% CI 1.21\u20132.41, p = 0.002), and were 2.1\u00d7 more likely to have overall work impairment (1.37\u20133.21, p = 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>These Corrona Registry data show that substantial skin involvement (BSA &gt; 3%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160963","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T20:10:43Z","timestamp":1497557443000},"page":"1151-1158","source":"Crossref","is-referenced-by-count":23,"title":["Clinical and Patient-reported Outcomes in Patients with Psoriatic Arthritis (PsA) by Body Surface Area Affected by Psoriasis: Results from the Corrona PsA\/Spondyloarthritis Registry"],"prefix":"10.3899","volume":"44","author":[{"given":"Philip J.","family":"Mease","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Karki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline B.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol 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