{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:16:09Z","timestamp":1789168569001,"version":"build-2803163510"},"reference-count":39,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To compare submaximal exercise capacity in patients with juvenile dermatomyositis (JDM) with controls, and analyze contributions of muscle, heart, and lung impairment in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Fifty-nine patients with JDM, with a mean 16.9 years after symptom onset, and 59 sex- and age-matched controls completed a 6-min walk test (6MWT) and a timed up and go (TUG) test. Muscle function, disease activity\/damage, and health-related quality of life (HRQOL) were assessed by validated tools; heart function by echocardiography and electrocardiography; and lung function by spirometry, DLCO, and body plethysmography. A thoracic high-resolution computed tomography (HRCT) scan and magnetic resonance imaging of the thighs were completed in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The 6MWT distance (6MWD) was 592 \u00b1 81 m in patients versus 649 \u00b1 79 m in controls (p &lt; 0.001), and 563 \u00b1 75 m in active versus 622 \u00b1 76 m in inactive JDM (p = 0.004). The TUG time was 13.1 \u00b1 2.1 s in patients versus 12.3 \u00b1 2.0 s in controls (p = 0.034), and 13.7 \u00b1 2.2 s in active versus 12.5 \u00b1 1.8 s in inactive JDM (p = 0.028). No statistically significant difference was found between inactive JDM and controls in either test. In patients, the Childhood Myositis Assessment Score influenced the 6MWD and TUG time the most, followed by a low DLCO and HRCT pathology in the 6MWT and forced vital capacity in the TUG test. Medical Outcomes Study Short Form-36 physical component summary correlated strongly with both tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Submaximal exercise capacity was reduced in patients with JDM, particularly those with active disease. This reduction was associated with muscle and lung dysfunction and poorer HRQOL.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.160997","type":"journal-article","created":{"date-parts":[[2017,4,2]],"date-time":"2017-04-02T00:20:15Z","timestamp":1491092415000},"page":"827-834","source":"Crossref","is-referenced-by-count":16,"title":["Submaximal Exercise Capacity in Juvenile Dermatomyositis after Longterm Disease: The Contribution of Muscle, Lung, and Heart Involvement"],"prefix":"10.3899","volume":"44","author":[{"given":"Kristin Schjander","family":"Berntsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tollisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kirkhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond Mogens","family":"Aal\u00f8kken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Brit","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar","family":"Sjaastad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Sanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,4,1]]},"reference":[{"key":"2018112909370432000_44.6.827.1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep302"},{"key":"2018112909370432000_44.6.827.2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20015"},{"key":"2018112909370432000_44.6.827.3","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.608376"},{"key":"2018112909370432000_44.6.827.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.23960"},{"key":"2018112909370432000_44.6.827.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.24904"},{"key":"2018112909370432000_44.6.827.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu146"},{"key":"2018112909370432000_44.6.827.7","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20203"},{"key":"2018112909370432000_44.6.827.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.131433"},{"key":"2018112909370432000_44.6.827.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203279"},{"key":"2018112909370432000_44.6.827.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137968"},{"key":"2018112909370432000_44.6.827.11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/acr.21637","article-title":"Quality of life in adults with juvenile-onset dermatomyositis: a case-control study","volume":"64","author":"Tollisen","year":"2012","journal-title":"Arthritis Care Res"},{"key":"2018112909370432000_44.6.827.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes232"},{"key":"2018112909370432000_44.6.827.13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2018112909370432000_44.6.827.14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120303"},{"key":"2018112909370432000_44.6.827.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21086"},{"key":"2018112909370432000_44.6.827.16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CCRPM.S10764","article-title":"Limitations to the 6-minute walk test in dermatomyositis with interstitial lung disease in comparison with idiopathic interstitial pneumonia","volume":"7","author":"Someya","year":"2013","journal-title":"Clin Med Insights Circ Respir Pulm Med"},{"key":"2018112909370432000_44.6.827.17","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150270"},{"key":"2018112909370432000_44.6.827.18","doi-asserted-by":"crossref","unstructured":"Benveniste O Rider LG ENMC Myositis Outcomes Study Group . 213th ENMC International Workshop: outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18\u201320 September 2015. 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