{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:15:53Z","timestamp":1787598953275,"version":"build-2736575974"},"reference-count":37,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>We evaluated the whole-spine computed tomography (CT) findings in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome to improve our understanding of this rare disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Whole-spine CT images obtained in 69 patients with SAPHO were reviewed. For each individual, a total of 25 vertebrae were evaluated for the distribution of affected vertebrae, CT manifestations of vertebral lesions, symmetry and location of distribution of the lesions on vertebrae, involvement pattern, and narrowing of adjacent intervertebral disc space. Paravertebral ligamentous ossifications, apophyseal joint disorders, and costovertebral joint disorders were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>All the 69 patients with SAPHO exhibited abnormalities on whole-spine CT. Sixty-four had vertebral lesions, 52 had paravertebral ossifications, and 47 had both. The vertebral lesions were observed in 441 vertebrae, with a predilection for thoracic spine. The lesions exhibited a mixture of cortical erosion, reactive osteosclerosis of surrounding cancellous bone, and syndesmophyte. They may be confined to the vertebral corner (65.1%) or be extensive, involving the endplate (34.9%). Corner lesions could start in any part of the epiphyseal ring. The lesions were asymmetrically distributed. The affected vertebrae were more consecutively involved in a \u201ckissing\u201d appearance (78.2%). Intervertebral disc spaces were usually normal or mildly narrowed. There were 320 foci of paravertebral ossifications observed, with a predilection for the supraspinous ligament. Paravertebral ossifications were delicate and segmental. Ossifications throughout annulus fibrosis and apophyseal joint were not observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Our investigation of the distributional, morphological features and the involvement pattern of spinal lesions in patients with SAPHO demonstrated distinct CT characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.161075","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T20:20:29Z","timestamp":1488399629000},"page":"648-654","source":"Crossref","is-referenced-by-count":27,"title":["Whole-spine Computed Tomography Findings in SAPHO Syndrome"],"prefix":"10.3899","volume":"44","author":[{"given":"Wenrui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"2018112909365927000_44.5.648.1","first-page":"187","article-title":"[Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases]","volume":"54","author":"Chamot","year":"1987","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"2018112909365927000_44.5.648.2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.170.3.9490935"},{"key":"2018112909365927000_44.5.648.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-003-0629-x"},{"key":"2018112909365927000_44.5.648.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-009-0047-8"},{"key":"2018112909365927000_44.5.648.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.08.014"},{"key":"2018112909365927000_44.5.648.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.08.004"},{"key":"2018112909365927000_44.5.648.7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jbspin.2013.04.016","article-title":"SAPHO syndrome","volume":"81","author":"Canella","year":"2014","journal-title":"Joint Bone Spine"},{"key":"2018112909365927000_44.5.648.8","first-page":"636","article-title":"Why \u201cspondylodiscitis,\u201d why \u201cSAPHO syndrome\u201d?","volume":"30","author":"Schilling","year":"2003","journal-title":"J Rheumatol"},{"key":"2018112909365927000_44.5.648.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.1.52"},{"key":"2018112909365927000_44.5.648.10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423051222"},{"key":"2018112909365927000_44.5.648.11","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4736"},{"key":"2018112909365927000_44.5.648.12","first-page":"2135","article-title":"SAPHO syndrome: a followup study of 19 cases with special emphasis on enthesis involvement","volume":"22","author":"Maugars","year":"1995","journal-title":"J Rheumatol"},{"key":"2018112909365927000_44.5.648.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0722-x"},{"key":"2018112909365927000_44.5.648.14","first-page":"189","article-title":"SAPHO syndrome\u2014a pictorial assay","volume":"32","author":"Khanna","year":"2012","journal-title":"Iowa Orthop J"},{"key":"2018112909365927000_44.5.648.15","first-page":"1100","article-title":"Lumbar spondylodiscitis in SAPHO syndrome: multimodality imaging findings","volume":"29","author":"Akisue","year":"2002","journal-title":"J Rheumatol"},{"key":"2018112909365927000_44.5.648.16","first-page":"896","article-title":"Ivory vertebra and palmoplantar pustulosis","volume":"34","author":"Blanco","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909365927000_44.5.648.17","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-002-0608-7"},{"key":"2018112909365927000_44.5.648.18","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.6.547"},{"key":"2018112909365927000_44.5.648.19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3109\/s101650200009","article-title":"Radiological features of long bones in synovitis, acne, pustulosis, hyperostosis, osteitis syndrome and their correlation with pathological findings","volume":"12","author":"Orui","year":"2002","journal-title":"Mod Rheumatol"},{"key":"2018112909365927000_44.5.648.20","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-200202000-00005"},{"key":"2018112909365927000_44.5.648.21","doi-asserted-by":"publisher","DOI":"10.1002\/art.24540"},{"key":"2018112909365927000_44.5.648.22","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090863"},{"key":"2018112909365927000_44.5.648.23","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1560-x"},{"key":"2018112909365927000_44.5.648.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.10.010"},{"key":"2018112909365927000_44.5.648.25","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140342"},{"key":"2018112909365927000_44.5.648.26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MNM.0000000000000451","article-title":"Is the bullhead sign on bone scintigraphy really common in the patient with SAPHO syndrome? A single-center study of a 16-year experience","volume":"37","author":"Fu","year":"2016","journal-title":"Nucl Med Commun"},{"key":"2018112909365927000_44.5.648.27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0049-0172(99)80027-4","article-title":"SAPHO syndrome: a long-term follow-up study of 120 cases","volume":"29","author":"Hayem","year":"1999","journal-title":"Semin Arthritis Rheun"},{"key":"2018112909365927000_44.5.648.28","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10067-012-1959-7","article-title":"Entheseal ultrasound abnormalities in patients with SAPHO syndrome","volume":"31","author":"Queiro","year":"2012","journal-title":"Clin Rheumatol"},{"key":"2018112909365927000_44.5.648.29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11832-014-0627-7","article-title":"SAPHO syndrome: a review","volume":"9","author":"Rukavina","year":"2015","journal-title":"J Child Orthop"},{"key":"2018112909365927000_44.5.648.30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1346-8138.2010.00931.x","article-title":"Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work","volume":"38","author":"Zhao","year":"2011","journal-title":"J Dermatol"},{"key":"2018112909365927000_44.5.648.31","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.33470"},{"key":"2018112909365927000_44.5.648.32","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-014-2025-0"},{"key":"2018112909365927000_44.5.648.33","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.157.1.2048545"},{"key":"2018112909365927000_44.5.648.34","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.098830"},{"key":"2018112909365927000_44.5.648.35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11547-013-0316-5","article-title":"Seronegative spondyloarthropathies: what radiologists should know","volume":"119","author":"Paparo","year":"2014","journal-title":"Radiol Med"},{"key":"2018112909365927000_44.5.648.36","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100426"},{"key":"2018112909365927000_44.5.648.37","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew015"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.161075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:15:29Z","timestamp":1543500929000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.161075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,1]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3899\/jrheum.161075"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.161075","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}