{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:44:40Z","timestamp":1789343080679,"version":"build-2803163510"},"reference-count":29,"publisher":"The Journal of Rheumatology","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate muscle impairment (isometric and dynamic) and disease activity during the first year after diagnosis of polymyositis (PM) and dermatomyositis (DM), and to study the relationship between muscle impairment, patient-reported health, and disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Seventy-two patients enrolled in the Swedish Myositis Register, 2003\u20132010, were followed prospectively. The Manual Muscle test (MMT-8; isometric muscle strength), the Functional Index of myositis test (FI-2; dynamic, repetitive muscle function), and disease activity (6-item core set) were retrieved at the time of diagnosis, and after 6 and 12 months. Self-reported health (Medical Outcomes Study Short Form-36; SF-36) was retrieved at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>At the time of diagnosis, median (Q1\u2013Q3) for the FI-2 was 27.2% (7.9\u201360.5%) of maximal score compared to 93.8% (92.5\u201398.8%) of maximal MMT-8. At 12 months, the FI-2 and the MMT-8 improved to 29.4% (16.5\u201360.7%; p &lt; 0.05) and 96.1% (88.1\u201399.4%), respectively (p &lt; 0.01). At 12 months, 45% of patients improved \u2265 20%, and 27% worsened \u2265 20% in FI-2 score, while 10% improved \u2265 20% in MMT-8. Physician\u2019s global visual analog scale (VAS), Health Assessment Questionnaire, and creatine phosphokinase levels improved significantly at 12 months (p &lt; 0.05\u20130.001) while patient\u2019s global and extramuscular VAS remained unchanged. The SF-36 physical function correlated strongly with the FI-2 (r<jats:sub>s<\/jats:sub> = 0.74; CI 0.55\u20130.85) and moderately with the MMT (r<jats:sub>s<\/jats:sub> = 0.54; CI 0.27\u20130.73), with lower correlations between muscle function and other SF-36 domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with PM\/DM were characterized by impaired dynamic repetitive muscle function (DRMF) that correlated well with patient-reported physical function. 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