{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:30:07Z","timestamp":1780471807086,"version":"3.54.1"},"reference-count":19,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A retrospective, multicenter, cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-\u03b1 treatment (Mantel-Cox chi-square = 6.43).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.161336","type":"journal-article","created":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T20:20:15Z","timestamp":1491078015000},"page":"822-826","source":"Crossref","is-referenced-by-count":27,"title":["Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis"],"prefix":"10.3899","volume":"44","author":[{"given":"Gabriele","family":"Simonini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bracaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cattalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Taddio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"De Libero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Pires Marafon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,4,1]]},"reference":[{"key":"2018112909370437000_44.6.822.1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/BOR.0000000000000316","article-title":"Uveitis in children","volume":"28","author":"Angeles-Han","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"2018112909370437000_44.6.822.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.05.006"},{"key":"2018112909370437000_44.6.822.3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22214"},{"key":"2018112909370437000_44.6.822.4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1177\/112067210701700509","article-title":"Methotrexate for uveitis associated with juvenile idiopathic arthritis: value and requirement for additional anti-inflammatory medication","volume":"17","author":"Heiligenhaus","year":"2007","journal-title":"Eur J Ophthalmol"},{"key":"2018112909370437000_44.6.822.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.09.048"},{"key":"2018112909370437000_44.6.822.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.021"},{"key":"2018112909370437000_44.6.822.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2008.03.007"},{"key":"2018112909370437000_44.6.822.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.22381"},{"key":"2018112909370437000_44.6.822.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"2018112909370437000_44.6.822.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.12.009"},{"key":"2018112909370437000_44.6.822.11","first-page":"1403","article-title":"Chronic uveitis in children with and without juvenile idiopathic arthritis: differences in patient characteristics and clinical course","volume":"35","author":"Heinz","year":"2008","journal-title":"J Rheumatol"},{"key":"2018112909370437000_44.6.822.12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3109\/09273948.2013.815785","article-title":"Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome","volume":"21","author":"Vitale","year":"2013","journal-title":"Ocul Immunol Inflamm"},{"key":"2018112909370437000_44.6.822.13","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ophtha.2013.09.041","article-title":"Factors predictive of remission of new-onset anterior uveitis","volume":"121","author":"Artornsombudh","year":"2014","journal-title":"Ophthalmology"},{"key":"2018112909370437000_44.6.822.14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.026955"},{"key":"2018112909370437000_44.6.822.15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3129\/i10-002","article-title":"Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre","volume":"45","author":"Chan","year":"2010","journal-title":"Can J Ophthalmol"},{"key":"2018112909370437000_44.6.822.16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajo.2015.12.034","article-title":"Remission of intermediate uveitis: incidence and predictive factors","volume":"164","author":"Kempen","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"2018112909370437000_44.6.822.17","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.184267"},{"key":"2018112909370437000_44.6.822.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.01.016"},{"key":"2018112909370437000_44.6.822.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.01.014"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.161336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:20:22Z","timestamp":1543501222000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.161336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,1]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,1]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.3899\/jrheum.161336"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.161336","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,1]]}}}