{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:24:44Z","timestamp":1782923084560,"version":"3.54.5"},"reference-count":17,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To study disease activity in women with juvenile idiopathic arthritis (JIA) during and after pregnancy. There is little previous knowledge about this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Our study included 135 pregnancies in 114 women with JIA. Disease activity was assessed at 7 timepoints before, throughout, and after pregnancy with the Disease Activity Score\u201328\u2013C-reactive protein 3 (DAS28-CRP3). Scores assessed at each visit were analyzed in a linear mixed model. The same statistical method was used to study self-reported physical function, pain, and mental health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Almost 80% of the women were in remission or had low disease activity during and after pregnancy. Although disease activity was stable throughout the study period, we found that DAS28 6 weeks postpartum increased significantly compared to the first trimester (2.78 vs 2.51, p = 0.005) and third trimester (2.78 vs 2.56, p = 0.011), respectively. DAS28 decreased significantly between 6 weeks and 12 months postpartum (2.78 vs 2.54, p = 0.014). Self-reported mental health was significantly better 6 weeks postpartum than before pregnancy (Medical Outcomes Study Short Form-36 Mental Health subscale 80.7 vs 76.5, p = 0.039). Self-reported pain was stable. Physical function was significantly worse in the third trimester of pregnancy than postpartum (Modified Health Assessment Questionnaire 0.57 vs 0.39, p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In women with JIA, disease activity was highest 6 weeks postpartum, but altogether low and stable in the period from planning pregnancy to 1 year after delivery.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.161410","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T20:11:15Z","timestamp":1512159075000},"page":"257-265","source":"Crossref","is-referenced-by-count":28,"title":["Disease Activity of Juvenile Idiopathic Arthritis during and after Pregnancy: A Prospective Multicenter Study"],"prefix":"10.3899","volume":"45","author":[{"given":"Kristin","family":"Ursin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stian","family":"Lydersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Skomsvoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Wallenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"2018112909375150000_45.2.257.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200237"},{"key":"2018112909375150000_45.2.257.2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000229759","article-title":"Adult outcomes of patients with juvenile idiopathic arthritis","volume":"1","author":"Minden","year":"2009","journal-title":"Horm Res"},{"key":"2018112909375150000_45.2.257.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206034"},{"key":"2018112909375150000_45.2.257.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.24003"},{"key":"2018112909375150000_45.2.257.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00801.x"},{"key":"2018112909375150000_45.2.257.6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.8.475"},{"key":"2018112909375150000_45.2.257.7","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909375150000_45.2.257.8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"2018112909375150000_45.2.257.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.22773"},{"key":"2018112909375150000_45.2.257.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"2018112909375150000_45.2.257.11","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200012150-00008"},{"issue":"Suppl 11","key":"2018112909375150000_45.2.257.12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/acr.20620","article-title":"Measures of functional status and quality of life in rheumatoid arthritis: Health Assessment Questionnaire Disability Index (HAQ), Modified Health Assessment Questionnaire (MHAQ), Multidimensional Health Assessment Questionnaire (MDHAQ), Health Assessment Questionnaire II (HAQ-II), Improved Health Assessment Questionnaire (Improved HAQ), and Rheumatoid Arthritis Quality of Life (RAQoL)","volume":"63","author":"Maska","year":"2011","journal-title":"Arthritis Care Res"},{"key":"2018112909375150000_45.2.257.13","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202281"},{"key":"2018112909375150000_45.2.257.14","first-page":"416","article-title":"Pregnancy in women of childbearing age affected by juvenile idiopathic arthritis (JIA)","volume":"29","author":"Alpigiani","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909375150000_45.2.257.15","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1219::AID-ANR19>3.0.CO;2-G"},{"key":"2018112909375150000_45.2.257.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033019"},{"key":"2018112909375150000_45.2.257.17","doi-asserted-by":"crossref","unstructured":"Eisenstein EM Berkun Y . 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