{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:51:21Z","timestamp":1790790681136,"version":"4.1.0"},"reference-count":49,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Accumulating evidence links juvenile idiopathic arthritis (JIA) to nonhost factors such as gut microbes. We hypothesize that children with new-onset JIA have increased intestinal bacterial translocation and circulating lipopolysaccharide (LPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We studied systemic treatment-naive patients with JIA [polyarticular JIA, n = 22, oligoarticular JIA, n = 31, and spondyloarthropathies (SpA), n = 16], patients with established inflammatory bowel disease\u2013related arthritis (IBD-RA, n = 11), and 34 healthy controls. We determined circulating IgG reactivity against LPS, LPS-binding protein (LBP), \u03b1-1-acid glycoprotein (\u03b1-1AGP), and C-reactive protein (CRP) in plasma or serum from these patients and controls. Juvenile Arthritis Disease Activity Score (JADAS-27) was calculated for patients with JIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Circulating anticore LPS antibody concentrations in patients with polyarticular JIA (p = 0.001), oligoarticular JIA (p = 0.024), and SpA (p = 0.001) were significantly greater than in controls, but there were no significant intergroup differences. Circulating LBP concentrations were also significantly greater in patients with polyarticular JIA (p = 0.001), oligoarticular JIA (p = 0.002), and SpA (p = 0.006) than controls, as were \u03b1-1AGP concentrations (p = 0.001, 0.001, and 0.003, respectively). No differences were observed between controls and patients with IBD-RA in any of the assays. Circulating concentrations of LBP and \u03b1-1AGP correlated strongly with CRP concentrations (r = 0.78 and r = 0.66, respectively). Anticore LPS antibody levels and CRP (r = 0.26), LBP (r = 0.24), and \u03b1-AGP (r = 0.22) concentrations had weaker correlations. JADAS-27 scores correlated with LBP (r = 0.66) and \u03b1-1AGP concentrations (r = 0.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Children with polyarticular JIA, oligoarticular JIA, and SpA have evidence of increased exposure to gut bacterial products. These data reinforce the concept that the intestine is a source of immune stimulation in JIA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.161589","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:20:13Z","timestamp":1505521213000},"page":"1624-1631","source":"Crossref","is-referenced-by-count":42,"title":["Serologic Evidence of Gut-driven Systemic Inflammation in Juvenile Idiopathic Arthritis"],"prefix":"10.3899","volume":"44","author":[{"given":"Lampros","family":"Fotis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurmohammad","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Baszis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Lev-Tzion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip I.","family":"Tarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"2018112909373353000_44.11.1624.1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12969-016-0104-6","article-title":"Gut microbiota-host interactions and juvenile idiopathic arthritis","volume":"14","author":"Arvonen","year":"2016","journal-title":"Pediatr Rheumatol Online J"},{"key":"2018112909373353000_44.11.1624.2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.autrev.2015.07.007","article-title":"Rheumatoid arthritis-celiac disease relationship: joints get that gut feeling","volume":"14","author":"Lerner","year":"2015","journal-title":"Autoimmun Rev"},{"key":"2018112909373353000_44.11.1624.3","doi-asserted-by":"publisher","DOI":"10.1080\/03009740701394005"},{"key":"2018112909373353000_44.11.1624.4","first-page":"128","article-title":"Increase of duodenal and ileal mucosal cytotoxic lymphocytes in juvenile idiopathic arthritis","volume":"28","author":"Arvonen","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909373353000_44.11.1624.5","first-page":"657","article-title":"Gastrointestinal symptoms and permeability in patients with juvenile idiopathic arthritis","volume":"21","author":"Weber","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909373353000_44.11.1624.6","first-page":"773","article-title":"Increased gut permeability in juvenile chronic arthritides. 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