{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:50:09Z","timestamp":1788522609069,"version":"build-2803163510"},"reference-count":28,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Our main objective was to assess the relationship between body composition (BC) and response to tumor necrosis factor-\u03b1 (TNF-\u03b1) blocker treatment in patients with ankylosing spondylitis (AS). Our secondary objective was to evaluate the change of BC after treatment, accounting for sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>All included patients fulfilled the modified New York criteria for AS and were naive to TNF-\u03b1 blocker. They were followed for at least 6 months after the start of etanercept or adalimumab. The Ankylosing Spondylitis Disease Activity Score containing C-reactive protein (ASDAS-CRP) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were reported. BC was assessed by whole body dual-energy X-ray absorptiometry. Body fat percentage (BF%), fat mass index (FMI), and fat free mass index (FFMI) were reported as absolute values and as percentiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Forty-one patients were included (61% men). The median followup was 14.3 months (interquartile range 8.4\u201319.4). After multivariate regression analysis, more fat at baseline (BF%, FMI, or FMI percentile) was significantly related with a lower chance of achieving a clinically important improvement of the ASDAS-CRP or BASDAI after treatment. The body composition did not change significantly after treatment, but there was a trend toward muscle recovery in men (FFMI change from 34.0th to 37.4th percentile).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Higher body fat content at baseline was independently associated with a worse response to treatment with TNF-\u03b1 blockers, measured by ASDAS-CRP and BASDAI change, and might contribute to the lower response rates in female patients. Also, there is a trend toward muscle mass recovery in male patients after treatment.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170094","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T20:10:17Z","timestamp":1500149417000},"page":"1355-1361","source":"Crossref","is-referenced-by-count":25,"title":["Fat Mass Lowers the Response to Tumor Necrosis Factor-\u03b1 Blockers in Patients with Ankylosing Spondylitis"],"prefix":"10.3899","volume":"44","author":[{"given":"Sebasti\u00e1n E.","family":"Ib\u00e1\u00f1ez Vodnizza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Nurmohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Visman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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