{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:58:45Z","timestamp":1780372725728,"version":"3.54.1"},"reference-count":31,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess the prevalence and association of renal dysfunction in patients with spondyloarthritis (SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) was an international study (22 participating countries from 4 continents) investigating comorbidities in SpA. Renal function was assessed based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease equation. SpA characteristics and risk factors for renal impairment were collected. Nonsteroidal antiinflammatory drug (NSAID) use was assessed based on current intake (last 3 mos).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of the 3984 patients recruited, 2098 (52.6%) were analyzed after excluding outliers and patients with no available eGFR measurement [male sex: 63.5%; age: 45.3 yrs; disease duration: 8.6 years; HLA-B27+: 73.1%; Bath Ankylosing Spondylitis Activity Index (BASDAI): 3.6\/10]. Overall, 153 patients (5.2%, mean age: 53.6 yrs) exhibited an eGFR &lt; 60 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>. In univariate analysis, renal impairment was associated with age (p &lt; 0.001), HLA-B27 positivity (p = 0.003), several cardiovascular (CV) risk factors (history of hypertension, p &lt; 0.001; systolic blood pressure, p = 0.009; diabetes, p = 0.005; and Framingham risk score, p &lt; 0.001), disease activity scores [BASDAI, p = 0.001; Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP), p &lt; 0.001], functional variables (Bath Ankylosing Spondylitis Functional Index, p &lt; 0.001), inflammatory biomarkers (erythrocyte and CRP, both p &lt; 0.001), and NSAID intake since onset of disease (percentage of days, p = 0.008). However, there was no association with disease duration, disease severity, or ASAS-NSAID score. In multivariate analysis, age (45\u201359 yrs: OR 1.9, &gt; 60 yrs: OR 6.2), HLA-B27 positivity (OR 0.51), and CRP (OR 1.3) remained significantly associated with eGFR &lt; 60 ml\/min\/1.73 m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Renal impairment was associated with age, HLA-B27 positivity, and inflammation, though not with CV risk factors, disease severity, or NSAID intake in patients with SpA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170133","type":"journal-article","created":{"date-parts":[[2018,4,15]],"date-time":"2018-04-15T07:35:13Z","timestamp":1523777713000},"page":"795-801","source":"Crossref","is-referenced-by-count":30,"title":["The Prevalence of Renal Impairment in Patients with Spondyloarthritis: Results from the International ASAS-COMOSPA Study"],"prefix":"10.3899","volume":"45","author":[{"given":"Marion","family":"Couderc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Molto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Tiple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Soubrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2018,4,15]]},"reference":[{"key":"2018112909384169000_45.6.795.1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00296-012-2624-9","article-title":"Renal involvement in ankylosing spondylitis: prevalence, pathology, response to TNF-a blocker","volume":"33","author":"Lee","year":"2013","journal-title":"Rheumatol Int"},{"key":"2018112909384169000_45.6.795.2","doi-asserted-by":"crossref","first-page":"e113602","DOI":"10.1371\/journal.pone.0113602","article-title":"Is nephrolithiasis an unrecognized extra-articular manifestation in ankylosing spondylitis? A prospective population-based Swedish national cohort study with matched general population comparator subjects","volume":"9","author":"Jakobsen","year":"2014","journal-title":"PLoS One"},{"key":"2018112909384169000_45.6.795.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.006"},{"key":"2018112909384169000_45.6.795.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.3.174"},{"key":"2018112909384169000_45.6.795.5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/acr.22176","article-title":"Estimating the occurrence of renal complications among persons with ankylosing spondylitis","volume":"66","author":"Levy","year":"2014","journal-title":"Arthritis Care Res"},{"key":"2018112909384169000_45.6.795.6","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.revmed.2005.07.017","article-title":"[Renal involvement in ankylosing spondylitis: concerning 210 cases]","volume":"26","author":"Ben Taarit","year":"2005","journal-title":"Rev Med Interne"},{"key":"2018112909384169000_45.6.795.7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nephro.2011.10.005","article-title":"[Renal abnormalities in ankylosing spondylitis]","volume":"8","author":"Samia","year":"2012","journal-title":"Nephrol Ther"},{"key":"2018112909384169000_45.6.795.8","first-page":"371","article-title":"Prevalence of subclinical amyloidosis in ankylosing spondylitis","volume":"34","author":"Singh","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909384169000_45.6.795.9","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0679-x"},{"key":"2018112909384169000_45.6.795.10","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2470"},{"key":"2018112909384169000_45.6.795.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208174"},{"key":"2018112909384169000_45.6.795.12","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"2018112909384169000_45.6.795.13","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"2018112909384169000_45.6.795.14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133488"},{"key":"2018112909384169000_45.6.795.15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-2-200307150-00013"},{"key":"2018112909384169000_45.6.795.16","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/03610919708813397","article-title":"Determination of the best significance level in forward logistic regression","volume":"26","author":"Lee","year":"1997","journal-title":"Commun Stat Simul Comput"},{"key":"2018112909384169000_45.6.795.17","unstructured":"Shtatland ES Cain E Barton MB . The perils of stepwise logistic regression and how to escape them using information criteria, and the Output Delivery System, SUGI\u201926 Proceedings, Paper 222\u201326. Cary: SAS Institute Inc."},{"key":"2018112909384169000_45.6.795.18","doi-asserted-by":"crossref","unstructured":"Hosmer DW Lemeshow S . Applied logistic regression. New York: John Wiley and Sons Inc.; 1989.","DOI":"10.2307\/2531779"},{"key":"2018112909384169000_45.6.795.19","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0"},{"key":"2018112909384169000_45.6.795.20","first-page":"375","article-title":"Low prevalence of renal, cardiac, pulmonary, and neurological extra-articular clinical manifestations in spondyloarthritis: analysis of the Brazilian Registry of Spondyloarthritis","volume":"52","author":"Rodrigues","year":"2012","journal-title":"Rev Bras Reumatol"},{"key":"2018112909384169000_45.6.795.21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1590\/S0482-50042011000500002","article-title":"IgA nephropathy in patients with spondyloarthritis followed-up at the Rheumatology Service of Hospital das Cl\u00ednicas\/UFMG","volume":"51","author":"Azevedo","year":"2011","journal-title":"Rev Bras Reumatol"},{"key":"2018112909384169000_45.6.795.22","doi-asserted-by":"publisher","DOI":"10.5301\/jn.5000169"},{"key":"2018112909384169000_45.6.795.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"2018112909384169000_45.6.795.24","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100668"},{"key":"2018112909384169000_45.6.795.25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken198"},{"key":"2018112909384169000_45.6.795.26","first-page":"612","article-title":"Atherosclerosis and cardiovascular disease in the spondyloarthritides, particularly ankylosing spondylitis and psoriatic arthritis","volume":"31","author":"Papagoras","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909384169000_45.6.795.27","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090667"},{"key":"2018112909384169000_45.6.795.28","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086777"},{"key":"2018112909384169000_45.6.795.29","doi-asserted-by":"publisher","DOI":"10.1002\/art.30581"},{"key":"2018112909384169000_45.6.795.30","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110593"},{"key":"2018112909384169000_45.6.795.31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064155"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.170133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T17:18:30Z","timestamp":1571159910000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.170133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,15]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.3899\/jrheum.170133"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.170133","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,15]]}}}