{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:00:32Z","timestamp":1792828832489,"version":"4.5.0"},"reference-count":41,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Large vessel uptake on positron emission tomography\/computerized tomography (PET\/CT) supports the diagnosis of giant cell arteritis (GCA). Its value, however, in patients without arteritis on temporal artery biopsy and in those receiving glucocorticoids remains unknown. We compared PET\/CT results in GCA patients with positive (TAB+) and negative temporal artery biopsies (TAB\u2212), and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients with new clinically diagnosed GCA starting treatment with glucocorticoids underwent temporal artery biopsy and PET\/CT. Using a visual semiquantitative approach, 18F-fluorodeoxyglucose (FDG) uptake was scored in 8 vascular territories and summed overall to give a total score in patients and matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Twenty-eight patients with GCA and 28 controls were enrolled. Eighteen patients with GCA were TAB+. Mean PET\/CT scores after an average of 11.9 days of prednisone were higher in patients with GCA compared to controls, for both total uptake (10.34 \u00b1 2.72 vs 7.73 \u00b1 2.56; p = 0.001), and in 6 of 8 specific vascular territories. PET\/CT scores were similar between TAB+ and TAB\u2212 patients with GCA. The optimal cutoff for distinguishing GCA cases from controls was a total PET\/CT score of \u2265 9, with an area under the receiver-operating characteristic curve of 0.75, sensitivity 71.4%, and specificity 64.3%. Among patients with GCA, these measures correlated with greater total PET\/CT scores: systemic symptoms (p = 0.015), lower hemoglobin (p = 0.009), and higher platelet count (p = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Vascular FDG uptake scores were increased in most patients with GCA despite exposure to prednisone; however, the sensitivity and specificity of PET\/CT in this setting were lower than those previously reported.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170138","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:20:13Z","timestamp":1505521213000},"page":"1859-1866","source":"Crossref","is-referenced-by-count":34,"title":["Positron Emission Tomography\/Computerized Tomography in Newly Diagnosed Patients with Giant Cell Arteritis Who Are Taking Glucocorticoids"],"prefix":"10.3899","volume":"44","author":[{"given":"Alison H.","family":"Clifford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Burrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew P.","family":"Bligh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan F.","family":"MacDougall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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