{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:48Z","timestamp":1791566448709,"version":"4.3.4"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Patients with polymyositis\/dermatomyositis (PM\/DM) who express anti-melanoma differentiation associated protein 5 (anti-MDA5) antibodies frequently present with interstitial lung disease (ILD). The aim of this study was to investigate the association of HLA-DRB1 with anti-MDA5 expression in PM\/DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The frequency of DRB1 alleles was compared among 70 patients with PM, 104 patients with DM, and 400 healthy controls in a Han Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Frequencies of DRB1*04:01 [17.0% vs 1.3%, corrected p value (p<jats:sub>c<\/jats:sub>) = 3.8 \u00d7 10<jats:sup>\u22128<\/jats:sup>, OR 16.2, 95% CI 6.6\u201339.7] and *12:02 (42.6% vs 19.3%, p<jats:sub>c<\/jats:sub> = 0.008, OR 3.1, 95% CI 1.7\u20135.7) were significantly higher in anti-MDA5\u2013positive patients with PM\/DM compared with the controls. The frequencies of DRB1*04:01 (p = 5.2 \u00d7 10<jats:sup>\u22126<\/jats:sup>, OR 17.1, 95% CI 5.3\u201354.9) and *12:02 (p = 3.8 \u00d7 10<jats:sup>\u22124<\/jats:sup>, OR 3.1, 95% CI 1.7\u20135.7) in anti-MDA5\u2013positive patients with DM-ILD were higher than in the controls, whereas the frequencies of DRB1*04:01 and *12:02 did not differ between the anti-MDA5\u2013negative patients with DM-ILD and controls. No difference in the frequency of DRB1 alleles, other than *04:01, carrying the \u201cshared epitope\u201d (SE), i.e., *01:01, *01:02, *04:05, and *10:01, was observed between the controls and patients with DM stratified by the presence of anti-MDA5 and ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>DRB1*04:01 and *12:02 confer susceptibility to anti-MDA5 antibody production in DM, which cannot be explained by the SE hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170165","type":"journal-article","created":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T00:10:17Z","timestamp":1500163817000},"page":"1389-1393","source":"Crossref","is-referenced-by-count":56,"title":["HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis"],"prefix":"10.3899","volume":"44","author":[{"given":"Zhiyong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2017,7,15]]},"reference":[{"key":"2018112909372156000_44.9.1389.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"2018112909372156000_44.9.1389.2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1840-0"},{"key":"2018112909372156000_44.9.1389.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000173991.74008.b0"},{"key":"2018112909372156000_44.9.1389.4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21985"},{"key":"2018112909372156000_44.9.1389.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.38137"},{"key":"2018112909372156000_44.9.1389.6","doi-asserted-by":"publisher","DOI":"10.1186\/ar1862"},{"key":"2018112909372156000_44.9.1389.7","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10067-015-2935-9","article-title":"Distinct 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