{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:44:04Z","timestamp":1780472644750,"version":"3.54.1"},"reference-count":25,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Evaluate growth in patients with polyarticular-course juvenile idiopathic arthritis (pcJIA) treated with tocilizumab (TCZ) for up to 2 years in a phase III trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients with pcJIA lasting at least 6 months and inadequate response to methotrexate received open-label TCZ intravenously every 4 weeks (randomly assigned to 8 or 10 mg\/kg if they weighed &lt; 30 kg; received 8 mg\/kg if they weighed \u2265 30 kg) for 16 weeks. Patients with JIA American College of Rheumatology 30 response at Week 16 were randomly assigned to TCZ or placebo for 24 weeks, with an open-label extension through Week 104. Mean \u00b1 SD height velocity (cm\/yr) and World Health Organization (WHO) height SD score (SDS) were measured in patients receiving \u2265 1 dose of TCZ who did not receive growth hormone and in patients whose baseline Tanner stage was \u2264 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The study included 187 of 188 patients (99.5%) with mean WHO height SDS \u22120.5 \u00b1 1.2, which was unrelated to age or disease duration (Spearman rank correlations r = 0.08 and r = \u22120.12, respectively). There were 123 patients at Tanner stage \u2264 3 at baseline, among whom 103 completed the study with 2 years of height SDS data. Mean height SDS increased from baseline to year 2 (+0.40, p &lt; 0.0001). In 74 of 103 patients (72%), height SDS was greater than at baseline, and mean height velocity was 6.7 \u00b1 2.0 cm\/year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Among patients with pcJIA at Tanner stage \u2264 3 at baseline, 72% (74\/103) had increased height SDS at the end of the study.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170326","type":"journal-article","created":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T07:29:46Z","timestamp":1530430186000},"page":"1173-1179","source":"Crossref","is-referenced-by-count":18,"title":["Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial"],"prefix":"10.3899","volume":"45","author":[{"given":"Kamal N.","family":"Bharucha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine 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