{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:46:06Z","timestamp":1774975566951,"version":"3.50.1"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Anakinra resulted in complete or partial remission in 3\/10 and 5\/10 patients, respectively, and no efficacy in 2\/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3\/7 and 4\/7 patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170684","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T01:10:14Z","timestamp":1516065014000},"page":"425-429","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature 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