{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:57:16Z","timestamp":1785297436830,"version":"3.55.0"},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Osteoarthritis (OA) is a condition that features inflammation and immune responses of innate and adaptive immunity. The role of T cells in knee OA pathogenesis is still unclear. Our aim was to characterize T cell functions and their clonality in patients with knee OA in peripheral blood (PB) and infrapatellar fat pads (IPFP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We isolated T cells from PB and IPFP of patients with knee OA and PB of healthy individuals and determined soluble mediators produced from these cells. In addition, we performed a clonal analysis of activated CD8+ T cells and compared the T cell receptor \u03b2-variable gene chain (TRBV) usages between T cells in PB and IPFP of patients with knee OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Our results suggest that in patients with knee OA, circulating T cells possess a more \u201ccytotoxic\u201d profile or rather impaired cytokine production, but the knee microenvironment allows for these T cells to produce proinflammatory cytokines [interleukin (IL)-1\u03b2, IL-6, tumor necrosis factor], IL-17, and interferon-\u03b3 within IPFP. Activated CD8+ IPFP T cells carry different repertoire distribution from those present in PB of patients with knee OA. Shared TRBV usage of activated CD8+ IPFP T cells among the 3 patients with knee OA was also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Our study describes the nature of T cells in knee OA that may be due to \u201cunhealthy\u201d aging or other factors that drive healthy aging T cells into a state of imbalance, thus contributing to the pathogenesis of knee OA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170775","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T11:19:22Z","timestamp":1539602362000},"page":"309-317","source":"Crossref","is-referenced-by-count":19,"title":["Functional and T Cell Receptor Repertoire Analyses of Peripheral Blood and Infrapatellar Fat Pad T Cells in Knee 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