{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:30:19Z","timestamp":1774953019886,"version":"3.50.1"},"reference-count":45,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess the reproducibility and the utility of the 6-minute walk test (6MWT) in systemic sclerosis (SSc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>All patients with SSc who underwent at least two 6MWT within a minimum 3-month interval plus simultaneous routine clinical, biological, and functional evaluations were consecutively enrolled in this observational study over 6 years. Following American Thoracic Society guidelines, each 6MWT was repeated twice to assess the 6-minute walk distance (6MWD) reproducibility, with the highest value being reported for subsequent analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Among 56 (38 female) included patients aged 46 \u00b1 SD 12.7 years, with 17 \u00b1 10 modified Rodnan skin score (mRSS) and 1 \u00b1 0.8 Scleroderma Health Assessment Questionnaire (SHAQ) at first referral, 277 6MWT evaluations (5 \u00b1 3.9 6MWT per patient) were performed over 23 \u00b1 22.5 months followup. Meanwhile, 8 deaths (87.5% SSc-related) occurred. The mean 6MWD absolute value was 457 \u00b1 117 m with a 4 \u00b1 2.2 mean Borg dyspnea score. The 6MWD intraclass correlation coefficient was 0.996 (95% CI 0.995\u20130.999, p &lt; 0.0001). In multivariate linear regression analysis, these factors were independently associated with a lower 6MWD: sex (R<jats:sup>2<\/jats:sup> = 0.47, p &lt; 0.0001), mRSS (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.008), tendon friction rub (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.003), SHAQ (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.02), muscle disability score (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.03), DLCO% (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.0008), and left ventricular ejection fraction (R<jats:sup>2<\/jats:sup> = 0.47, p = 0.006). The 6MWD at first referral was an independent predictor for the overall mortality (HR 0.99, 95% CI 0.988\u20130.999) and the SSc-related mortality (HR 0.99, 95% CI 0.988\u20130.999).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>We show strong reproducibility for the 6MWD and confirm the 6MWT utility to assess the overall prognosis of patients with SSc.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.170994","type":"journal-article","created":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T07:29:46Z","timestamp":1530430186000},"page":"1273-1280","source":"Crossref","is-referenced-by-count":23,"title":["Reproducibility and Utility of the 6-minute Walk Test in Systemic 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