{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:13:08Z","timestamp":1790363588117,"version":"4.1.0"},"reference-count":48,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Ankylosing spondylitis (AS) is associated with increased risk for cardiovascular disease (CVD). Left ventricular (LV) hypertrophy is a strong precursor for clinical CVD. The aim of our study was to assess whether having AS was associated with increased prevalence of LV hypertrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Clinical and echocardiographic data from 139 AS patients and 126 age- and sex-matched controls was used. LV mass was calculated according to guidelines and indexed to height<jats:sup>2.7<\/jats:sup>. LV hypertrophy was considered present if LV mass index was &gt; 49.2 g\/m<jats:sup>2.7<\/jats:sup> in men and &gt; 46.7 g\/m<jats:sup>2.7<\/jats:sup> in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients with AS were on average 49 \u00b1 12 years old, and 60% were men. The prevalence of hypertension (HTN; 35% vs 41%) and diabetes (5% vs 2%) was similar among patients and controls, while patients with AS had higher serum C-reactive protein level (CRP; p &lt; 0.001). The prevalence of LV hypertrophy was higher in patients with AS compared to controls (15% vs 6%, p = 0.01). In multivariable logistic regression analysis, having AS was associated with OR 6.3 (95% CI 2.1\u201319.3, p = 0.001) of having LV hypertrophy independent of the presence of HTN, diabetes, and obesity. In multivariable linear regression analyses, having AS was also associated with higher LV mass (\u03b2 0.15, p = 0.007) after adjusting for CVD risk factors including sex, body mass index, systolic blood pressure, diabetes, and serum CRP (multiple R<jats:sup>2<\/jats:sup> = 0.41, p &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Having AS was associated with increased prevalence of LV hypertrophy independent of CVD risk factors. This finding strengthens the indication for thorough CVD risk assessment in patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.171124","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T07:35:15Z","timestamp":1527838515000},"page":"1249-1255","source":"Crossref","is-referenced-by-count":11,"title":["Ankylosing Spondylitis Is Associated with Increased Prevalence of Left Ventricular Hypertrophy"],"prefix":"10.3899","volume":"45","author":[{"given":"Helga","family":"Midtb\u00f8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gerdts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger 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