{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:29Z","timestamp":1792670789899,"version":"4.5.0"},"reference-count":14,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n Objective.<\/jats:title>\n Forced vital capacity (FVC) and DLCO are used for screening of systemic sclerosis\u2013associated interstitial lung disease (SSc-ILD). The study purpose was to determine the sensitivity, specificity, and negative predictive value (NPV) (proportion of true negative screening tests) of FVC and DLCO thresholds for SSc-ILD on chest high-resolution computed tomography (HRCT) scans.<\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n Patients fulfilling American College of Rheumatology 2013 SSc criteria with a chest HRCT scan and pulmonary function tests (PFT) were studied. A thoracic radiologist quantified radiographic ILD. Optimal FVC and DLCO % predicted thresholds for ILD were identified using receiver-operating characteristic curves. The FVC and DLCO combinations with greatest sensitivity and specificity were also determined. Subanalysis was performed in patients with positive Scl-70 autoantibodies.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n The study included 265 patients. Of 188 (71%) with radiographic ILD, 59 (31%) had \u201cnormal\u201d FVC (\u2265 80% predicted), and 65 out of 151 (43%) had \u201cnormal\u201d DLCO (\u2265 60% predicted). FVC < 80% (sensitivity 0.69, specificity 0.73), and DLCO < 62% (sensitivity 0.60, specificity 0.70) were optimal thresholds for radiographic SSc-ILD. All FVC and DLCO threshold combinations evaluated had NPV < 0.70. The NPV for radiographic ILD for FVC < 80% was lower in patients with positive Scl-70 autoantibody (NPV = 0.05) compared to negative Scl-70 autoantibody (NPV = 0.57).<\/jats:p>\n <\/jats:sec>\n \n Conclusion.<\/jats:title>\n Radiographic ILD is prevalent in SSc despite \u201cnormal\u201d PFT. No % predicted FVC or DLCO threshold combinations yielded high NPV for SSc-ILD screening. \u201cNormal\u201d FVC and DLCO in patients with SSc, especially those with positive Scl-70 autoantibodies, should not obviate consideration of HRCT for ILD evaluation.<\/jats:p>\n <\/jats:sec>","DOI":"10.3899\/jrheum.171362","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T07:15:25Z","timestamp":1538378125000},"page":"1572-1576","source":"Crossref","is-referenced-by-count":69,"title":["Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis"],"prefix":"10.3899","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-5545","authenticated-orcid":false,"given":"Kimberly","family":"Showalter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-0949","authenticated-orcid":false,"given":"Gerald","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungwha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Dematte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowland W.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Hinchcliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"2018112909391311000_45.11.1572.1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.lpm.2014.08.002","article-title":"Interstitial lung disease in systemic sclerosis","volume":"43","author":"Wells","year":"2014","journal-title":"Presse Med"},{"key":"2018112909391311000_45.11.1572.2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2213-0802-2-4","article-title":"Diagnosis and management of interstitial lung disease","volume":"2","author":"Meyer","year":"2014","journal-title":"Transl Respir 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Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.171362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:32:13Z","timestamp":1543501933000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.171362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,1]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.3899\/jrheum.171362"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.171362","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}