{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:13:01Z","timestamp":1793412781497,"version":"4.5.0"},"reference-count":39,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor\u2013positive JIA; (c) enthesitis\/spondylitis-related JIA; and (d) early-onset antinuclear antibody\u2013positive JIA. The other forms were gathered under the term \u201cothers.\u201d These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>\n                      An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term\n                      <jats:italic>JIA<\/jats:italic>\n                      . These preliminary criteria will be formally validated with a dedicated project.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3899\/jrheum.180168","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T07:15:22Z","timestamp":1538378122000},"page":"190-197","source":"Crossref","is-referenced-by-count":503,"title":["Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus"],"prefix":"10.3899","volume":"46","author":[{"given":"Alberto","family":"Martini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ravelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadej","family":"Avcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Beresford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Burgos-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Cuttica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman T.","family":"Ilowite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Khubchandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Laxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Petty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico M.","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pistorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolino","family":"Ruperto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Pediatric Rheumatology International Trials Organization (PRINTO)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"2019020109251862000_46.2.190.1","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997","volume":"25","author":"Petty","year":"1998","journal-title":"J Rheumatol"},{"key":"2019020109251862000_46.2.190.2","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"2019020109251862000_46.2.190.3","first-page":"1900","article-title":"Are the number of joints involved or the presence of psoriasis still useful tools to identify homogeneous disease entities in juvenile idiopathic arthritis?","volume":"30","author":"Martini","year":"2003","journal-title":"J Rheumatol"},{"key":"2019020109251862000_46.2.190.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201388"},{"key":"2019020109251862000_46.2.190.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.20945"},{"key":"2019020109251862000_46.2.190.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.30076"},{"key":"2019020109251862000_46.2.190.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210025"},{"key":"2019020109251862000_46.2.190.8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.40350","article-title":"Review: genetics and the classification of arthritis in adults and children","volume":"70","author":"Nigrovic","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2019020109251862000_46.2.190.9","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1002\/art.38875","article-title":"The biologic basis of clinical heterogeneity in juvenile idiopathic arthritis","volume":"66","author":"Eng","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2019020109251862000_46.2.190.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520779112"},{"key":"2019020109251862000_46.2.190.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210324"},{"key":"2019020109251862000_46.2.190.12","unstructured":"Delbecq AL Van de Ven AH Gustafson DH . Group techniques for program planning. A guide to nominal group and Delphi processes. Glenview, IL: Scott, Foresman; 1975."},{"key":"2019020109251862000_46.2.190.13","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-008-0025-6"},{"key":"2019020109251862000_46.2.190.14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg403"},{"key":"2019020109251862000_46.2.190.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21230"},{"key":"2019020109251862000_46.2.190.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.22002"},{"key":"2019020109251862000_46.2.190.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380602"},{"key":"2019020109251862000_46.2.190.18","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R"},{"key":"2019020109251862000_46.2.190.19","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.1.38"},{"key":"2019020109251862000_46.2.190.20","doi-asserted-by":"publisher","DOI":"10.1002\/art.20349"},{"key":"2019020109251862000_46.2.190.21","doi-asserted-by":"publisher","DOI":"10.1002\/art.23248"},{"key":"2019020109251862000_46.2.190.22","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"2019020109251862000_46.2.190.23","first-page":"424","article-title":"Preliminary criteria for classification of adult Still\u2019s disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"2019020109251862000_46.2.190.24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2019020109251862000_46.2.190.25","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208642"},{"key":"2019020109251862000_46.2.190.26","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101501"},{"key":"2019020109251862000_46.2.190.27","doi-asserted-by":"publisher","DOI":"10.1002\/art.27657"},{"key":"2019020109251862000_46.2.190.28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.berh.2016.08.003","article-title":"Adult-onset Still\u2019s disease: advances in the treatment","volume":"30","author":"Castaneda","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2019020109251862000_46.2.190.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.022"},{"key":"2019020109251862000_46.2.190.30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141627"},{"key":"2019020109251862000_46.2.190.31","doi-asserted-by":"publisher","DOI":"10.1002\/art.23437"},{"key":"2019020109251862000_46.2.190.32","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/art.40498","article-title":"IL1RN variation influences both disease susceptibility and response to recombinant human interleukin-1 receptor antagonist therapy in systemic juvenile idiopathic arthritis","volume":"70","author":"Arthur","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2019020109251862000_46.2.190.33","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205372"},{"key":"2019020109251862000_46.2.190.34","first-page":"825","article-title":"Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis","volume":"30","author":"Van Rossum","year":"2003","journal-title":"J Rheumatol"},{"key":"2019020109251862000_46.2.190.35","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-31"},{"key":"2019020109251862000_46.2.190.36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.berh.2015.04.010","article-title":"Role of autoantibody testing","volume":"28","author":"Aggarwal","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2019020109251862000_46.2.190.37","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"2019020109251862000_46.2.190.38","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.37"},{"key":"2019020109251862000_46.2.190.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70348-3"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.180168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T01:07:55Z","timestamp":1571965675000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.180168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,1]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.3899\/jrheum.180168"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.180168","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}