{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:21:46Z","timestamp":1792549306156,"version":"4.5.0"},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n Objective.<\/jats:title>\n We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.<\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n A systematic review of PubMed, EMBASE\/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring system conducted by a clinician\/health professional.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n Ten studies were eligible for final analysis, which included 237 patients, of which prepartum data were available for 204 patients. Postpartum disease activity was recorded in 135 pregnancies.<\/jats:p>\n <\/jats:sec>\n \n Conclusion.<\/jats:title>\n Disease activity improved in 60% of patients with RA in pregnancy and flared in 46.7% postpartum.<\/jats:p>\n <\/jats:sec>","DOI":"10.3899\/jrheum.180226","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T07:15:18Z","timestamp":1541056518000},"page":"245-250","source":"Crossref","is-referenced-by-count":141,"title":["Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis"],"prefix":"10.3899","volume":"46","author":[{"given":"Hannah","family":"Jethwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"2019030109253049000_46.3.245.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.037580"},{"key":"2019030109253049000_46.3.245.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker302"},{"key":"2019030109253049000_46.3.245.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.24003"},{"key":"2019030109253049000_46.3.245.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260915"},{"key":"2019030109253049000_46.3.245.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6367.750"},{"key":"2019030109253049000_46.3.245.6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.016881"},{"key":"2019030109253049000_46.3.245.7","doi-asserted-by":"crossref","first-page":"w13644","DOI":"10.4414\/smw.2012.13644","article-title":"Pregnancy mediated improvement of rheumatoid arthritis","volume":"142","author":"Forger","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"2019030109253049000_46.3.245.8","first-page":"3358","article-title":"Maternal cytokines and disease severity influence pregnancy outcomes in women with rheumatoid arthritis","volume":"29","author":"Atta","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019030109253049000_46.3.245.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033019"},{"key":"2019030109253049000_46.3.245.10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.trsl.2013.02.007","article-title":"The physiologic increase in expression of some type I IFN-inducible genes during pregnancy is not associated with improved disease activity in pregnant patients with rheumatoid arthritis","volume":"161","author":"Weix","year":"2013","journal-title":"Transl Res"},{"key":"2019030109253049000_46.3.245.11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029538"},{"key":"2019030109253049000_46.3.245.12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/03009748309098556","article-title":"Comparison between serum alpha 2-pregnancy-associated globulin and activity of rheumatoid arthritis and ankylosing spondylitis during pregnancy","volume":"12","author":"Ostensen","year":"1983","journal-title":"Scand J Rheumatol"},{"key":"2019030109253049000_46.3.245.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.21663"},{"key":"2019030109253049000_46.3.245.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.24914"},{"key":"2019030109253049000_46.3.245.15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104331"},{"key":"2019030109253049000_46.3.245.16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202539"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.180226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:51:29Z","timestamp":1775256689000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.180226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,1]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.3899\/jrheum.180226"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.180226","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}