{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:37:50Z","timestamp":1793144270463,"version":"4.5.0"},"reference-count":25,"publisher":"The Journal of Rheumatology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We retrospectively analyzed NVC images of 190 patients with AS [females\/males 3.63, mean age 49.7 \u00b1 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non\u2013anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody\u2013negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female\/male ratio 4.13\/1, mean age 53.9 \u00b1 17.6 yrs) for NVC measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p &lt; 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180355","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T07:23:49Z","timestamp":1542266629000},"page":"279-284","source":"Crossref","is-referenced-by-count":58,"title":["Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International 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