{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:24:46Z","timestamp":1767921886558,"version":"3.49.0"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To quantify healthcare resource utilization (HRU), work loss, and annual direct and indirect healthcare costs among patients with systemic sclerosis (SSc) compared to matched controls in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Data were obtained from a large US commercial claims database. Patients were \u2265 18 years old at the index date (first SSc diagnosis) and had \u2265 1 SSc diagnosis in the inpatient (IP) or emergency room (ER) setting, or \u2265 2 SSc diagnoses on 2 different dates in the outpatient (OP) setting between January 1, 2005, and March 31, 2015; continuous enrollment was required during the followup period (12 months after the index date). Individuals with no SSc diagnoses were matched 1:1 to patients with SSc. Wilcoxon signed-rank and McNemar tests were used for comparisons and regressions with generalized estimating equations for adjusted OR (aOR) and incidence rate ratios (IRR) between 2 cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There were 2192 pairs of patients with SSc and matched controls included (mean age 57.6 yrs; 84.3% female); of these, 233 were eligible for work loss\/indirect cost analyses. Compared to matched controls, patients with SSc had significantly higher HRU and costs during the 1-year followup period, IP admissions (adjusted IRR = 2.4), IP hospitalization days (adjusted IRR = 3.1), ER visits (adjusted IRR = 2.0), OP visits (adjusted IRR = 2.3), and days of work loss (adjusted IRR = 2.6). The adjusted difference in annual direct and indirect costs was US$12,820 and $3103, respectively (all p &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with SSc had a high direct and indirect economic burden postdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180445","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T17:17:10Z","timestamp":1550251030000},"page":"920-927","source":"Crossref","is-referenced-by-count":16,"title":["Economic Burden among Commercially Insured Patients with Systemic Sclerosis in the United 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