{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:04:15Z","timestamp":1790078655132,"version":"4.0.1"},"reference-count":44,"publisher":"The Journal of Rheumatology","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate the correlation between changes in radiological quantitative assessment with changes in clinical and functional assessment from baseline to 3 months in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Twenty-eight patients with RA [methotrexate (MTX) and anti-tumor necrosis factor\u2013\u03b1 (TNF-\u03b1) group with high disease activity (n = 18); and MTX group with low disease activity (n = 10)] underwent assessments at baseline and 3 months: clinical [28-joint count Disease Activity Score (DAS28)], functional [Health Assessment Questionnaire (HAQ) and Michigan Hand Outcome Questionnaire (MHQ)], and imaging-based [3 Tesla magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT)]. MR images were evaluated semiquantitatively [RA MRI scoring (RAMRIS)] and quantitatively for the volume of synovitis and bone marrow edema (BME) lesions. Erosion volumes were measured using HR-pQCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>After 3 months, the anti-TNF-\u03b1 group demonstrated an improvement in disease activity through DAS28, HAQ, and MHQ. MRI showed significant decreases in synovitis and BME volume for the anti-TNF-\u03b1 group, and significant increases in the MTX group. HR-pQCT showed significant decreases in bone erosion volume for the anti-TNF-\u03b1 group, and significant increases in the MTX group. No significance was observed using RAMRIS. Changes in synovitis, BME, and erosion volumes, but not RAMRIS, were significantly correlated with changes in DAS28, HAQ, and MHQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Quantitative measures were more sensitive than semiquantitative grading when evaluating structural and inflammatory changes with treatment, and were associated with patient clinical and functional outcomes. Multimodality imaging with 3T MRI and HR-pQCT may provide promising biomarkers that help determine disease progression and therapy response.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180496","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T17:17:49Z","timestamp":1550251069000},"page":"676-684","source":"Crossref","is-referenced-by-count":14,"title":["Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis"],"prefix":"10.3899","volume":"46","author":[{"given":"Tomohiro","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Mamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pedoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Burghardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Heilmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Imboden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2019080920151989000_46.7.676.1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1706::AID-ANR20>3.0.CO;2-Z"},{"key":"2019080920151989000_46.7.676.2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22353"},{"key":"2019080920151989000_46.7.676.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh199"},{"key":"2019080920151989000_46.7.676.4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.39480","article-title":"2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2019080920151989000_46.7.676.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(98)80042-7"},{"key":"2019080920151989000_46.7.676.6","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1080\/14397595.2016.1254361","article-title":"Relationship between roentgenographic joint destruction in the hands and functional disorders among patients with rheumatoid arthritis","volume":"27","author":"Yasui","year":"2017","journal-title":"Mod Rheumatol"},{"key":"2019080920151989000_46.7.676.7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12955-016-0584-6","article-title":"An empirical evaluation of the SF-12, SF-6D, EQ-5D and Michigan Hand Outcome Questionnaire in patients with rheumatoid arthritis of the hand","volume":"15","author":"Dritsaki","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"2019080920151989000_46.7.676.8","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0140-6736(89)92442-2","article-title":"Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis","volume":"1","author":"van der Heijde","year":"1989","journal-title":"Lancet"},{"key":"2019080920151989000_46.7.676.9","first-page":"1385","article-title":"OMERACT rheumatoid arthritis magnetic resonance imaging studies. 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