{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:28:36Z","timestamp":1767997716782,"version":"3.49.0"},"reference-count":8,"publisher":"The Journal of Rheumatology","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Evaluate enthesitis, physical function, and health-related quality of life (HRQOL) among patients with psoriatic arthritis (PsA) who are naive to anti\u2013tumor necrosis factor agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In PSUMMIT 1 and 2, patients with PsA were randomized to placebo or ustekinumab 45 mg or 90 mg. Enthesitis was assessed at weeks 0 and 24 (Maastricht Ankylosing Spondylitis Enthesitis Score). Assessments included Health Assessment Questionnaire\u2013Disability Index (HAQ-DI), Medical Outcomes Study Short Form-36 (SF-36) physical component summary\/mental component summary (PCS\/MCS), and American College of Rheumatology 20 (ACR20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>At Week 24, 21 had worsened enthesitis, 158 had improved enthesitis, and 412 had unchanged enthesitis. Improved enthesitis was associated with improvements in HAQ-DI and SF-36 MCS. Results were similar for ACR20 responders and nonresponders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Improvement in enthesitis at Week 24 was associated with improvements in physical function\/HRQOL regardless of ACR20 response.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180792","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T16:15:48Z","timestamp":1554135348000},"page":"1458-1461","source":"Crossref","is-referenced-by-count":13,"title":["Association Between Enthesitis and Health-related Quality of Life in Psoriatic Arthritis in Biologic-naive Patients from 2 Phase III Ustekinumab Trials"],"prefix":"10.3899","volume":"46","author":[{"given":"Iain B.","family":"McInnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice B.","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Kafka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. James","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Proton","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Kavanaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2019110109251008000_46.11.1458.1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/acr.23174","article-title":"Clinical enthesitis in a prospective longitudinal psoriatic arthritis cohort: incidence, prevalence, characteristics, and outcome","volume":"69","author":"Polachek","year":"2017","journal-title":"Arthritis Care Res"},{"key":"2019110109251008000_46.11.1458.2","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/acr.23249","article-title":"Clinical characteristics, disease activity, and patient-reported outcomes in psoriatic arthritis patients with dactylitis or enthesitis: results from the Corrona Psoriatic Arthritis\/Spondyloarthritis Registry","volume":"69","author":"Mease","year":"2017","journal-title":"Arthritis Care Res"},{"key":"2019110109251008000_46.11.1458.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60594-2"},{"key":"2019110109251008000_46.11.1458.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204655"},{"key":"2019110109251008000_46.11.1458.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.2.127"},{"key":"2019110109251008000_46.11.1458.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380602"},{"key":"2019110109251008000_46.11.1458.7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13075-017-1399-5","article-title":"The association between sonographic enthesitis and radiographic damage in psoriatic arthritis","volume":"19","author":"Polachek","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"2019110109251008000_46.11.1458.8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s10067-018-4012-7","article-title":"Psoriatic arthritis: tissue-directed inflammation?","volume":"37","author":"Cafaro","year":"2018","journal-title":"Clin Rheumatol"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.180792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T16:26:41Z","timestamp":1572625601000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.180792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,1]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.3899\/jrheum.180792"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.180792","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}