{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:25:28Z","timestamp":1790112328347,"version":"4.0.1"},"reference-count":50,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess prognostic factors of antimelanoma differentiation-associated gene 5 antibody (anti-MDA5)\u2013positive dermatomyositis\/clinically amyopathic DM\u2013associated interstitial lung disease (DM\/CADM-ILD) and evaluate the use of serum chitotriosidase, a marker for macrophage activation, as a potential biomarker in anti-MDA5-positive DM\/CADM-ILD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>This retrospective study included 30 patients with anti-MDA5\u2013positive DM\/CADM-ILD. The clinical characteristics and laboratory findings at the time of diagnosis were analyzed. Serum chitotriosidase levels were measured in the 30 patients, in 21 healthy controls, and in 25 patients with anti-aminoacyl-tRNA synthetase antibody\u2013positive (anti-ARS)-polymyositis (PM)\/DM\/CADM-ILD, and the potential of serum chitotriosidase as a prognostic biomarker in anti-MDA5\u2013positive DM\/CADM-ILD was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The median serum chitotriosidase level in patients with anti-MDA5\u2013positive DM\/CADM-ILD was 17.3 ng\/ml, which was higher than that in healthy controls and anti-ARS\u2013PM\/DM\/CADM-ILD (2.0 and 8.9 ng\/ml, respectively). Of the 30 patients, 10 died of respiratory failure associated with DM\/CADM-ILD deterioration. Cox hazard analysis demonstrated that higher serum chitotriosidase level and lower PaO<jats:sub>2<\/jats:sub> value were significant predictors of a poor outcome. Using optimal cutoff levels according to receiver-operating characteristic curve analyses, chitotriosidase \u2265 23.5 ng\/ml, ferritin \u2265 800 ng\/ml, and Krebs von den Lungen\u20136 \u2265 720 U\/ml were significantly associated with a poor prognosis. Serum chitotriosidase levels were negatively correlated with PaO<jats:sub>2<\/jats:sub> and percentage predicted forced vital capacity. The survival rate was significantly poorer in patients with high chitotriosidase levels (\u2265 23.5 ng\/ml) than in those with low chitotriosidase levels (&lt; 23.5 ng\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Serum chitotriosidase may be a potential biomarker for predicting a poor prognosis in patients with anti-MDA5\u2013positive DM\/CADM-ILD.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180825","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T12:37:18Z","timestamp":1557923838000},"page":"935-942","source":"Crossref","is-referenced-by-count":39,"title":["Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody\u2013positive Dermatomyositis-associated Interstitial Lung 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