{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:42:37Z","timestamp":1791600157030,"version":"4.3.4"},"reference-count":19,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Synovial perfusion variables were associated with remission (p &lt; 0.05) and cartilage quality (p &lt; 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p &lt; 0.05). Synovial perfusion improved in nonresponders over time (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.180832","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T17:20:39Z","timestamp":1552670439000},"page":"15-19","source":"Crossref","is-referenced-by-count":9,"title":["Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging"],"prefix":"10.3899","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-6207","authenticated-orcid":false,"given":"Philipp","family":"Sewerin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Brinks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"M\u00fcller-Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Fichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Eichner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Ostendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vordenb\u00e4umen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"2022092307201004000_47.1.15.1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s13075-014-0452-x","article-title":"Dynamic contrast-enhanced magnetic resonance imaging of metacarpophalangeal joints reflects histological signs of synovitis in rheumatoid arthritis","volume":"16","author":"Vordenb\u00e4umen","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2022092307201004000_47.1.15.2","first-page":"117","article-title":"Inflammation and vascularisation markers of arthroscopically-guided finger joint synovial biopsies reflect global disease activity in rheumatoid arthritis","volume":"32","author":"Vordenb\u00e4umen","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"2022092307201004000_47.1.15.3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s10067-017-3628-3","article-title":"Contribution of subjective Disease Activity Score 28 (DAS28) components to the response to treatment of rheumatoid arthritis","volume":"36","author":"Son","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2022092307201004000_47.1.15.4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/acr.22532","article-title":"Contribution of the subjective components of the disease activity score to the response to biologic treatment in rheumatoid arthritis","volume":"67","author":"Jurgens","year":"2015","journal-title":"Arthritis Care Res"},{"key":"2022092307201004000_47.1.15.5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12891-017-1528-y","article-title":"Silent progression in patients with rheumatoid arthritis: is DAS28 remission an insufficient goal in RA? 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