{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:10:45Z","timestamp":1778620245045,"version":"3.51.4"},"reference-count":19,"publisher":"The Journal of Rheumatology","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>The Pregnancy and Lactation Autoimmune Network (PLAN) registry was established to evaluate the concerns of women with autoimmune or inflammatory rheumatic diseases (AIRD) pertaining to pregnancy and lactation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>The registry was started as a survey of patients with AIRD at a single rheumatology specialty center in November 2016 and included questions regarding fertility, pregnancy, miscarriages, and lactation before and after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The study included 154 subjects from the PLAN registry. More than half (52%) of respondents indicated that their diagnosis negatively changed their views on pregnancy and nearly a third (30%) decided not to have children after AIRD diagnosis. Most (66%) women were concerned that medication use during the childbearing process would affect the baby. One-third (34%) indicated their views on breastfeeding negatively changed as a result of their disease diagnosis. The rates and duration of breastfeeding did not differ significantly for babies born before or after the mothers\u2019 diagnosis (p = 0.50 and p = 0.21, respectively). Eighteen women in our study avoided breastfeeding or stopped breastfeeding earlier than planned to start a medication (including etanercept, adalimumab, hydroxychloroquine, and certolizumab) they believed to be contraindicated during lactation. The PLAN registry included 19 women who breastfed 22 babies while being exposed to a disease-modifying antirheumatic drug or biologic. None of these 19 women reported a delay in their children\u2019s developmental milestones or higher infection rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>This study highlights an unmet need in patients with AIRD of childbearing potential for data and education regarding pregnancy and lactation.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.181067","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T16:22:31Z","timestamp":1554135751000},"page":"149-154","source":"Crossref","is-referenced-by-count":15,"title":["Perceptions of Pregnancy and Lactation from the Pregnancy and Lactation Autoimmune Network Registry"],"prefix":"10.3899","volume":"47","author":[{"given":"Brooke S.","family":"Mills","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn H.","family":"Dao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen M.","family":"Tecson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily F.","family":"Beil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Cush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2022092307201007000_47.1.149.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24003"},{"key":"2022092307201007000_47.1.149.2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1219::AID-ANR19>3.0.CO;2-G"},{"key":"2022092307201007000_47.1.149.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.011"},{"key":"2022092307201007000_47.1.149.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.24914"},{"key":"2022092307201007000_47.1.149.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140583"},{"key":"2022092307201007000_47.1.149.6","doi-asserted-by":"publisher","DOI":"10.1177\/1010539515624964"},{"key":"2022092307201007000_47.1.149.7","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.3.237"},{"key":"2022092307201007000_47.1.149.8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/ajcn\/70.4.525","article-title":"Breast-feeding and cognitive development: a meta-analysis","volume":"70","author":"Anderson","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"2022092307201007000_47.1.149.9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802758"},{"key":"2022092307201007000_47.1.149.10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208840"},{"key":"2022092307201007000_47.1.149.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.01.009"},{"key":"2022092307201007000_47.1.149.12","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.430"},{"key":"2022092307201007000_47.1.149.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.22159"},{"key":"2022092307201007000_47.1.149.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.089268"},{"key":"2022092307201007000_47.1.149.15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/0961203316686704","article-title":"Systemic lupus erythematosus and risk of preterm birth: a systematic review and meta-analysis of observational studies","volume":"26","author":"Wei","year":"2017","journal-title":"Lupus"},{"key":"2022092307201007000_47.1.149.16","first-page":"S11","article-title":"Women\u2019s perception of teratogenic risk","volume":"82","author":"Koren","year":"1991","journal-title":"Can J Public Health"},{"key":"2022092307201007000_47.1.149.17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90186-5"},{"key":"2022092307201007000_47.1.149.18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3109\/00365521.2014.920913","article-title":"Self-reported adherence to medical treatment, breastfeeding behaviour, and disease activity during the postpartum period in women with Crohn\u2019s disease","volume":"49","author":"Julsgaard","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"2022092307201007000_47.1.149.19","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200005)43:5<1010::AID-ANR8>3.0.CO;2-O"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.181067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:25:18Z","timestamp":1663943118000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.181067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,1]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.3899\/jrheum.181067"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.181067","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}