{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:08:57Z","timestamp":1778580537612,"version":"3.51.4"},"reference-count":26,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>The genetic component of ankylosing spondylitis (AS) development is \u223c90%. Of the known heritability, \u223c20% is explained by HLA-B27, and 113 identified AS-associated single-nucleotide polymorphisms (SNP) account for \u223c7.4%. The objectives were to construct a weighted genetic risk score (wGRS) using currently known genome-wide susceptibility SNP, and to evaluate its predictive ability for AS in the Norwegian population-based Nord-Tr\u00f8ndelag Health Study (HUNT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>AS cases (n = 164) and controls (n = 49,032) were from the second (1995\u20131997) and third (2006\u20132008) waves of the HUNT study, to which the entire adult population of the northern region of Tr\u00f8ndelag was invited. A wGRS based on 110 SNP weighted by published OR for AS was constructed, representing each person\u2019s carriage of all risk variants. Logistic regression models including the wGRS alone or in combination with HLA-B27 carrier state and other adjustment variables (sex, age, smoking, body mass index, and hypertension) were developed. Discrimination among models was compared using area under the curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The wGRS was associated with AS (OR 1.7, 95% CI 1.4\u20132.1), but showed low discrimination (AUC 0.62, 95% CI 0.58\u20130.67). HLA-B27 was significantly associated with AS (OR 50, 95% CI 32\u201381), showing high discrimination (AUC 0.88, 95% CI 0.85\u20130.90). Combining the wGRS and HLA-B27 improved prediction (AUC 0.90, 95% CI 0.87\u20130.92; p &lt; 0.001 vs wGRS alone, p &lt; 0.01 vs HLA-B27 alone). Further inclusion of adjustment variables gave a small improvement (AUC 0.91, 95% CI 0.89\u20130.94; p = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Prediction in a population-based setting based on all currently known AS susceptibility SNP was better than HLA-B27 carrier state alone, although the improvement was small and of uncertain clinical value.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.181209","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T12:22:48Z","timestamp":1554121368000},"page":"204-210","source":"Crossref","is-referenced-by-count":14,"title":["Prediction of Ankylosing Spondylitis in the HUNT Study by a Genetic Risk Score Combining 110 Single-nucleotide Polymorphisms of Genome-wide Significance"],"prefix":"10.3899","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-3927","authenticated-orcid":false,"given":"Sina","family":"Rostami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-8663","authenticated-orcid":false,"given":"Mari","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-8211","authenticated-orcid":false,"given":"Matthew A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-9744","authenticated-orcid":false,"given":"Kristian","family":"Hveem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oddgeir L.","family":"Holmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-1690","authenticated-orcid":false,"given":"Lars G.","family":"Fritsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-3889","authenticated-orcid":false,"given":"Vibeke","family":"Videm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2020020109251875000_47.2.204.1","doi-asserted-by":"crossref","unstructured":"Raychaudhuri SP Deodhar A . The classification and diagnostic criteria of ankylosing spondylitis. J Autoimmun 2014;48\u201349:128\u201333.","DOI":"10.1016\/j.jaut.2014.01.015"},{"key":"2020020109251875000_47.2.204.2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/acr.22512","article-title":"Time trends in incidence, clinical features, and cardiovascular disease in ankylosing spondylitis over three decades: a population-based study","volume":"67","author":"Wright","year":"2015","journal-title":"Arthritis Care Res"},{"key":"2020020109251875000_47.2.204.3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1586\/14737167.2014.957679","article-title":"Health-related quality of life in patients with ankylosing spondylitis: a comprehensive review","volume":"14","author":"Kotsis","year":"2014","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"2020020109251875000_47.2.204.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"2020020109251875000_47.2.204.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401015"},{"key":"2020020109251875000_47.2.204.6","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B"},{"key":"2020020109251875000_47.2.204.7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3528"},{"key":"2020020109251875000_47.2.204.8","doi-asserted-by":"publisher","DOI":"10.1080\/19485565.2013.774628"},{"key":"2020020109251875000_47.2.204.9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.gde.2015.06.005","article-title":"Genomic risk prediction of complex human disease and its clinical application","volume":"33","author":"Abraham","year":"2015","journal-title":"Curr Opin Genet Dev"},{"key":"2020020109251875000_47.2.204.10","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys095"},{"key":"2020020109251875000_47.2.204.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2020020109251875000_47.2.204.12","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161396"},{"key":"2020020109251875000_47.2.204.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0171-3"},{"key":"2020020109251875000_47.2.204.14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"2020020109251875000_47.2.204.15","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153717"},{"key":"2020020109251875000_47.2.204.16","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3643"},{"key":"2020020109251875000_47.2.204.17","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160347"},{"key":"2020020109251875000_47.2.204.18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000864"},{"key":"2020020109251875000_47.2.204.19","first-page":"229","article-title":"Genetic diagnostic profiling in axial spondyloarthritis: A real world study","volume":"35","author":"Thomas","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"2020020109251875000_47.2.204.20","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes056"},{"key":"2020020109251875000_47.2.204.21","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835257c5"},{"key":"2020020109251875000_47.2.204.22","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111307"},{"key":"2020020109251875000_47.2.204.23","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140353"},{"key":"2020020109251875000_47.2.204.24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fgene.2013.00138","article-title":"Evaluation of genetic risk score models in the presence of interaction and linkage disequilibrium","volume":"4","author":"Che","year":"2013","journal-title":"Front Genet"},{"key":"2020020109251875000_47.2.204.25","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204133"},{"key":"2020020109251875000_47.2.204.26","first-page":"1203","article-title":"SAT0710 Risk association for ankylosing spondylitis using a genetic risk score combining 110 SNPs of genome-wide significance in the population-based HUNT study","volume":"77","author":"Rostami","year":"2018","journal-title":"Ann Rheum Dis"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.181209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T12:26:55Z","timestamp":1580560015000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.181209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,1]]},"published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.3899\/jrheum.181209"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.181209","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}